| Regular Season: Week 1 |
 Raiders |
at |
 Broncos |
Sunday, September 6, 1981 |
3:00PM |
OAK 7, DEN 9 |
| Regular Season: Week 2 |
Raiders |
at |
 Vikings |
Monday, September 14, 1981 |
3:00PM |
OAK 36, MIN 10 |
| Regular Season: Week 3 |
 Seahawks |
at |
Raiders |
Sunday, September 20, 1981 |
3:00PM |
SEA 10, OAK 20 |
| Regular Season: Week 4 |
Raiders |
at |
 Lions |
Sunday, September 27, 1981 |
3:00PM |
OAK 0, DET 16 |
| Regular Season: Week 5 |
Broncos |
at |
Raiders |
Sunday, October 4, 1981 |
3:00PM |
DEN 17, OAK 0 |
| Regular Season: Week 6 |
Raiders |
at |
 Chiefs |
Sunday, October 11, 1981 |
3:00PM |
OAK 0, KC 27 |
| Regular Season: Week 7 |
 Buccaneers |
at |
Raiders |
Sunday, October 18, 1981 |
3:00PM |
TB 16, OAK 18 |
| Regular Season: Week 8 |
Chiefs |
at |
Raiders |
Sunday, October 25, 1981 |
2:00PM |
KC 28, OAK 17 |
| Regular Season: Week 9 |
 Patriots |
at |
Raiders |
Sunday, November 1, 1981 |
3:00PM |
NE 17, OAK 27 |
| Regular Season: Week 10 |
Raiders |
at |
 Oilers |
Sunday, November 8, 1981 |
3:00PM |
OAK 16, HOU 17 |
| Regular Season: Week 11 |
Raiders |
at |
 Dolphins |
Sunday, November 15, 1981 |
3:00PM |
OAK 33, MIA 17 |
| Regular Season: Week 12 |
 Chargers |
at |
Raiders |
Sunday, November 22, 1981 |
3:00PM |
SD 55, OAK 21 |
| Regular Season: Week 13 |
Raiders |
at |
Seahawks |
Sunday, November 29, 1981 |
3:00PM |
OAK 32, SEA 31 |
| Regular Season: Week 14 |
 Steelers |
at |
Raiders |
Monday, December 7, 1981 |
3:00PM |
PIT 27, OAK 30 |
| Regular Season: Week 15 |
 Bears |
at |
Raiders |
Sunday, December 13, 1981 |
3:00PM |
CHI 23, OAK 6 |
| Regular Season: Week 16 |
Raiders |
at |
Chargers |
Monday, December 21, 1981 |
3:00PM |
OAK 10, SD 23 |