| Regular Season: Week 1 |
 49ers |
at |
 Falcons |
Sunday, September 3, 2000 |
1:00PM |
SF 28, ATL 36 |
| Regular Season: Week 2 |
 Panthers |
at |
49ers |
Sunday, September 10, 2000 |
4:15PM |
CAR 38, SF 22 |
| Regular Season: Week 3 |
49ers |
at |
 Rams |
Sunday, September 17, 2000 |
1:00PM |
SF 24, STL 41 |
| Regular Season: Week 4 |
49ers |
at |
 Cowboys |
Sunday, September 24, 2000 |
1:00PM |
SF 41, DAL 24 |
| Regular Season: Week 5 |
 Cardinals |
at |
49ers |
Sunday, October 1, 2000 |
4:15PM |
ARI 20, SF 27 |
| Regular Season: Week 6 |
 Raiders |
at |
49ers |
Sunday, October 8, 2000 |
4:15PM |
OAK 34, SF 28 |
| Regular Season: Week 7 |
49ers |
at |
 Packers |
Sunday, October 15, 2000 |
4:15PM |
SF 28, GB 31 |
| Regular Season: Week 8 |
49ers |
at |
Panthers |
Sunday, October 22, 2000 |
1:00PM |
SF 16, CAR 34 |
| Regular Season: Week 9 |
Rams |
at |
49ers |
Sunday, October 29, 2000 |
4:05PM |
STL 34, SF 24 |
| Regular Season: Week 10 |
49ers |
at |
 Saints |
Sunday, November 5, 2000 |
1:00PM |
SF 15, NO 31 |
| Regular Season: Week 11 |
 Chiefs |
at |
49ers |
Sunday, November 12, 2000 |
4:05PM |
KC 7, SF 21 |
| Regular Season: Week 12 |
Falcons |
at |
49ers |
Sunday, November 19, 2000 |
4:15PM |
ATL 6, SF 16 |
| Regular Season: Week 14 |
49ers |
at |
 Chargers |
Sunday, December 3, 2000 |
4:05PM |
SF 45, SD 17 |
| Regular Season: Week 15 |
Saints |
at |
49ers |
Sunday, December 10, 2000 |
4:15PM |
NO 31, SF 27 |
| Regular Season: Week 16 |
 Bears |
at |
49ers |
Sunday, December 17, 2000 |
4:05PM |
CHI 0, SF 17 |
| Regular Season: Week 17 |
49ers |
at |
 Broncos |
Saturday, December 23, 2000 |
4:15PM |
SF 9, DEN 38 |