| Regular Season: Week 1 |
 Cardinals |
at |
 49ers |
Sunday, September 7, 2008 |
4:15PM |
ARI 23, SF 13 |
| Regular Season: Week 2 |
49ers |
at |
 Seahawks |
Sunday, September 14, 2008 |
4:05PM |
SF 33, SEA 30 |
| Regular Season: Week 3 |
 Lions |
at |
49ers |
Sunday, September 21, 2008 |
4:05PM |
DET 13, SF 31 |
| Regular Season: Week 4 |
49ers |
at |
 Saints |
Sunday, September 28, 2008 |
1:00PM |
SF 17, NO 31 |
| Regular Season: Week 5 |
 Patriots |
at |
49ers |
Sunday, October 5, 2008 |
4:15PM |
NE 30, SF 21 |
| Regular Season: Week 6 |
 Eagles |
at |
49ers |
Sunday, October 12, 2008 |
4:15PM |
PHI 40, SF 26 |
| Regular Season: Week 7 |
49ers |
at |
 Giants |
Sunday, October 19, 2008 |
1:00PM |
SF 17, NYG 29 |
| Regular Season: Week 8 |
Seahawks |
at |
49ers |
Sunday, October 26, 2008 |
4:15PM |
SEA 34, SF 13 |
| Regular Season: Week 10 |
49ers |
at |
Cardinals |
Monday, November 10, 2008 |
8:30PM |
SF 24, ARI 29 |
| Regular Season: Week 11 |
 Rams |
at |
49ers |
Sunday, November 16, 2008 |
4:05PM |
STL 16, SF 35 |
| Regular Season: Week 12 |
49ers |
at |
 Cowboys |
Sunday, November 23, 2008 |
1:00PM |
SF 22, DAL 35 |
| Regular Season: Week 13 |
49ers |
at |
 Bills |
Sunday, November 30, 2008 |
1:00PM |
SF 10, BUF 3 |
| Regular Season: Week 14 |
 Jets |
at |
49ers |
Sunday, December 7, 2008 |
4:05PM |
NYJ 14, SF 24 |
| Regular Season: Week 15 |
49ers |
at |
 Dolphins |
Sunday, December 14, 2008 |
1:00PM |
SF 9, MIA 14 |
| Regular Season: Week 16 |
49ers |
at |
Rams |
Sunday, December 21, 2008 |
1:00PM |
SF 17, STL 16 |
| Regular Season: Week 17 |
 Redskins |
at |
49ers |
Sunday, December 28, 2008 |
4:15PM |
WAS 24, SF 27 |