| Regular Season: Week 1 |
 49ers |
at |
 Seahawks |
Sunday, September 12, 2010 |
4:15PM |
SF 6, SEA 31 |
| Regular Season: Week 2 |
 Saints |
at |
49ers |
Monday, September 20, 2010 |
8:30PM |
NO 25, SF 22 |
| Regular Season: Week 3 |
49ers |
at |
 Chiefs |
Sunday, September 26, 2010 |
1:00PM |
SF 10, KC 31 |
| Regular Season: Week 4 |
49ers |
at |
 Falcons |
Sunday, October 3, 2010 |
1:00PM |
SF 14, ATL 16 |
| Regular Season: Week 5 |
 Eagles |
at |
49ers |
Sunday, October 10, 2010 |
8:20PM |
PHI 27, SF 24 |
| Regular Season: Week 6 |
 Raiders |
at |
49ers |
Sunday, October 17, 2010 |
4:05PM |
OAK 9, SF 17 |
| Regular Season: Week 7 |
49ers |
at |
 Panthers |
Sunday, October 24, 2010 |
1:00PM |
SF 20, CAR 23 |
| Regular Season: Week 8 |
 Broncos |
at |
49ers |
Sunday, October 31, 2010 |
1:00PM |
DEN 16, SF 24 |
| Regular Season: Week 10 |
 Rams |
at |
49ers |
Sunday, November 14, 2010 |
4:15PM |
STL 20, SF 23 |
| Regular Season: Week 11 |
 Buccaneers |
at |
49ers |
Sunday, November 21, 2010 |
4:05PM |
TB 21, SF 0 |
| Regular Season: Week 12 |
49ers |
at |
 Cardinals |
Monday, November 29, 2010 |
8:30PM |
SF 27, ARI 6 |
| Regular Season: Week 13 |
49ers |
at |
 Packers |
Sunday, December 5, 2010 |
1:00PM |
SF 16, GB 34 |
| Regular Season: Week 14 |
Seahawks |
at |
49ers |
Sunday, December 12, 2010 |
4:05PM |
SEA 21, SF 40 |
| Regular Season: Week 15 |
49ers |
at |
 Chargers |
Thursday, December 16, 2010 |
8:20PM |
SF 7, SD 34 |
| Regular Season: Week 16 |
49ers |
at |
Rams |
Sunday, December 26, 2010 |
1:00PM |
SF 17, STL 25 |
| Regular Season: Week 17 |
Cardinals |
at |
49ers |
Sunday, January 2, 2011 |
4:15PM |
ARI 7, SF 38 |