| Regular Season: Week 1 |
 Cardinals |
at |
 49ers |
Sunday, September 13, 2020 |
4:25PM |
ARI 24, SF 20 |
| Regular Season: Week 2 |
49ers |
at |
 Jets |
Sunday, September 20, 2020 |
1:00PM |
SF 31, NYJ 13 |
| Regular Season: Week 3 |
49ers |
at |
 Giants |
Sunday, September 27, 2020 |
1:00PM |
SF 36, NYG 9 |
| Regular Season: Week 4 |
 Eagles |
at |
49ers |
Sunday, October 4, 2020 |
8:20PM |
PHI 25, SF 20 |
| Regular Season: Week 5 |
 Dolphins |
at |
49ers |
Sunday, October 11, 2020 |
4:05PM |
MIA 43, SF 17 |
| Regular Season: Week 6 |
 Rams |
at |
49ers |
Sunday, October 18, 2020 |
8:20PM |
LA 16, SF 24 |
| Regular Season: Week 7 |
49ers |
at |
 Patriots |
Sunday, October 25, 2020 |
4:25PM |
SF 33, NE 6 |
| Regular Season: Week 8 |
49ers |
at |
 Seahawks |
Sunday, November 1, 2020 |
4:25PM |
SF 27, SEA 37 |
| Regular Season: Week 9 |
 Packers |
at |
49ers |
Thursday, November 5, 2020 |
8:20PM |
GB 34, SF 17 |
| Regular Season: Week 10 |
49ers |
at |
 Saints |
Sunday, November 15, 2020 |
4:25PM |
SF 13, NO 27 |
| Regular Season: Week 12 |
49ers |
at |
Rams |
Sunday, November 29, 2020 |
4:05PM |
SF 23, LA 20 |
| Regular Season: Week 13 |
 Bills |
at |
49ers |
Monday, December 7, 2020 |
8:15PM |
BUF 34, SF 24 |
| Regular Season: Week 14 |
 Washington |
at |
49ers |
Sunday, December 13, 2020 |
4:25PM |
WAS 23, SF 15 |
| Regular Season: Week 15 |
49ers |
at |
 Cowboys |
Sunday, December 20, 2020 |
1:00PM |
SF 33, DAL 41 |
| Regular Season: Week 16 |
49ers |
at |
Cardinals |
Saturday, December 26, 2020 |
4:30PM |
SF 20, ARI 12 |
| Regular Season: Week 17 |
Seahawks |
at |
49ers |
Sunday, January 3, 2021 |
4:25PM |
SEA 26, SF 23 |