| Regular Season: Week 1 |
 Bears |
at |
 Packers |
Sunday, September 7, 1980 |
3:00PM |
CHI 6, GB 12 |
| Regular Season: Week 2 |
 Saints |
at |
Bears |
Sunday, September 14, 1980 |
3:00PM |
NO 3, CHI 22 |
| Regular Season: Week 3 |
 Vikings |
at |
Bears |
Sunday, September 21, 1980 |
3:00PM |
MIN 34, CHI 14 |
| Regular Season: Week 4 |
Bears |
at |
 Steelers |
Sunday, September 28, 1980 |
3:00PM |
CHI 3, PIT 38 |
| Regular Season: Week 5 |
 Buccaneers |
at |
Bears |
Monday, October 6, 1980 |
3:00PM |
TB 0, CHI 23 |
| Regular Season: Week 6 |
Bears |
at |
Vikings |
Sunday, October 12, 1980 |
3:00PM |
CHI 7, MIN 13 |
| Regular Season: Week 7 |
 Lions |
at |
Bears |
Sunday, October 19, 1980 |
3:00PM |
DET 7, CHI 24 |
| Regular Season: Week 8 |
Bears |
at |
 Eagles |
Sunday, October 26, 1980 |
2:00PM |
CHI 14, PHI 17 |
| Regular Season: Week 9 |
Bears |
at |
 Browns |
Monday, November 3, 1980 |
3:00PM |
CHI 21, CLE 27 |
| Regular Season: Week 10 |
 Redskins |
at |
Bears |
Sunday, November 9, 1980 |
3:00PM |
WAS 21, CHI 35 |
| Regular Season: Week 11 |
 Oilers |
at |
Bears |
Sunday, November 16, 1980 |
3:00PM |
HOU 10, CHI 6 |
| Regular Season: Week 12 |
Bears |
at |
 Falcons |
Sunday, November 23, 1980 |
3:00PM |
CHI 17, ATL 28 |
| Regular Season: Week 13 |
Bears |
at |
Lions |
Thursday, November 27, 1980 |
3:00PM |
CHI 23, DET 17 |
| Regular Season: Week 14 |
Packers |
at |
Bears |
Sunday, December 7, 1980 |
3:00PM |
GB 7, CHI 61 |
| Regular Season: Week 15 |
 Bengals |
at |
Bears |
Sunday, December 14, 1980 |
3:00PM |
CIN 17, CHI 14 |
| Regular Season: Week 16 |
Bears |
at |
Buccaneers |
Saturday, December 20, 1980 |
3:00PM |
CHI 14, TB 13 |