| Regular Season: Week 1 |
 Steelers |
at |
 Bills |
Sunday, September 3, 1978 |
3:00PM |
PIT 28, BUF 17 |
| Regular Season: Week 2 |
 Jets |
at |
Bills |
Sunday, September 10, 1978 |
3:00PM |
NYJ 21, BUF 20 |
| Regular Season: Week 3 |
Bills |
at |
 Dolphins |
Sunday, September 17, 1978 |
3:00PM |
BUF 24, MIA 31 |
| Regular Season: Week 4 |
 Colts |
at |
Bills |
Sunday, September 24, 1978 |
3:00PM |
BAL 17, BUF 24 |
| Regular Season: Week 5 |
 Chiefs |
at |
Bills |
Sunday, October 1, 1978 |
3:00PM |
KC 13, BUF 28 |
| Regular Season: Week 6 |
Bills |
at |
Jets |
Sunday, October 8, 1978 |
3:00PM |
BUF 14, NYJ 45 |
| Regular Season: Week 7 |
Bills |
at |
 Oilers |
Sunday, October 15, 1978 |
3:00PM |
BUF 10, HOU 17 |
| Regular Season: Week 8 |
 Bengals |
at |
Bills |
Sunday, October 22, 1978 |
3:00PM |
CIN 0, BUF 5 |
| Regular Season: Week 9 |
Bills |
at |
 Browns |
Sunday, October 29, 1978 |
2:00PM |
BUF 20, CLE 41 |
| Regular Season: Week 10 |
 Patriots |
at |
Bills |
Sunday, November 5, 1978 |
3:00PM |
NE 14, BUF 10 |
| Regular Season: Week 11 |
Dolphins |
at |
Bills |
Sunday, November 12, 1978 |
3:00PM |
MIA 25, BUF 24 |
| Regular Season: Week 12 |
Bills |
at |
 Buccaneers |
Sunday, November 19, 1978 |
3:00PM |
BUF 10, TB 31 |
| Regular Season: Week 13 |
 Giants |
at |
Bills |
Sunday, November 26, 1978 |
3:00PM |
NYG 17, BUF 41 |
| Regular Season: Week 14 |
Bills |
at |
Chiefs |
Sunday, December 3, 1978 |
3:00PM |
BUF 10, KC 14 |
| Regular Season: Week 15 |
Bills |
at |
Patriots |
Sunday, December 10, 1978 |
3:00PM |
BUF 24, NE 26 |
| Regular Season: Week 16 |
Bills |
at |
Colts |
Sunday, December 17, 1978 |
3:00PM |
BUF 21, BAL 14 |