| Regular Season: Week 1 |
 Colts |
at |
 Bills |
Sunday, September 9, 1990 |
3:00PM |
IND 10, BUF 26 |
| Regular Season: Week 2 |
Bills |
at |
 Dolphins |
Sunday, September 16, 1990 |
3:00PM |
BUF 7, MIA 30 |
| Regular Season: Week 3 |
Bills |
at |
 Jets |
Monday, September 24, 1990 |
3:00PM |
BUF 30, NYJ 7 |
| Regular Season: Week 4 |
 Broncos |
at |
Bills |
Sunday, September 30, 1990 |
3:00PM |
DEN 28, BUF 29 |
| Regular Season: Week 5 |
 Raiders |
at |
Bills |
Sunday, October 7, 1990 |
3:00PM |
RAI 24, BUF 38 |
| Regular Season: Week 7 |
Jets |
at |
Bills |
Sunday, October 21, 1990 |
3:00PM |
NYJ 27, BUF 30 |
| Regular Season: Week 8 |
Bills |
at |
 Patriots |
Sunday, October 28, 1990 |
2:00PM |
BUF 27, NE 10 |
| Regular Season: Week 9 |
Bills |
at |
 Browns |
Sunday, November 4, 1990 |
3:00PM |
BUF 42, CLE 0 |
| Regular Season: Week 10 |
 Cardinals |
at |
Bills |
Sunday, November 11, 1990 |
3:00PM |
PHO 14, BUF 45 |
| Regular Season: Week 11 |
Patriots |
at |
Bills |
Sunday, November 18, 1990 |
3:00PM |
NE 0, BUF 14 |
| Regular Season: Week 12 |
Bills |
at |
 Oilers |
Monday, November 26, 1990 |
3:00PM |
BUF 24, HOU 27 |
| Regular Season: Week 13 |
 Eagles |
at |
Bills |
Sunday, December 2, 1990 |
3:00PM |
PHI 23, BUF 30 |
| Regular Season: Week 14 |
Bills |
at |
Colts |
Sunday, December 9, 1990 |
3:00PM |
BUF 31, IND 7 |
| Regular Season: Week 15 |
Bills |
at |
 Giants |
Saturday, December 15, 1990 |
3:00PM |
BUF 17, NYG 13 |
| Regular Season: Week 16 |
Dolphins |
at |
Bills |
Sunday, December 23, 1990 |
3:00PM |
MIA 14, BUF 24 |
| Regular Season: Week 17 |
Bills |
at |
 Redskins |
Sunday, December 30, 1990 |
3:00PM |
BUF 14, WAS 29 |
| Divisional Playoffs: Week 19 |
Dolphins |
at |
Bills |
Saturday, January 12, 1991 |
3:00PM |
MIA 34, BUF 44 |
| Conference Championship: Week 20 |
Raiders |
at |
Bills |
Sunday, January 20, 1991 |
3:00PM |
RAI 3, BUF 51 |
| Super Bowl: Week 21 |
Bills |
at |
Giants |
Sunday, January 27, 1991 |
3:00PM |
BUF 19, NYG 20 |