| Regular Season: Week 1 |
 Jaguars |
at |
 Bills |
Sunday, September 12, 2004 |
1:00PM |
JAC 13, BUF 10 |
| Regular Season: Week 2 |
Bills |
at |
 Raiders |
Sunday, September 19, 2004 |
4:15PM |
BUF 10, OAK 13 |
| Regular Season: Week 4 |
 Patriots |
at |
Bills |
Sunday, October 3, 2004 |
1:00PM |
NE 31, BUF 17 |
| Regular Season: Week 5 |
Bills |
at |
 Jets |
Sunday, October 10, 2004 |
4:05PM |
BUF 14, NYJ 16 |
| Regular Season: Week 6 |
 Dolphins |
at |
Bills |
Sunday, October 17, 2004 |
1:00PM |
MIA 13, BUF 20 |
| Regular Season: Week 7 |
Bills |
at |
 Ravens |
Sunday, October 24, 2004 |
1:00PM |
BUF 6, BAL 20 |
| Regular Season: Week 8 |
 Cardinals |
at |
Bills |
Sunday, October 31, 2004 |
1:00PM |
ARI 14, BUF 38 |
| Regular Season: Week 9 |
Jets |
at |
Bills |
Sunday, November 7, 2004 |
1:00PM |
NYJ 17, BUF 22 |
| Regular Season: Week 10 |
Bills |
at |
Patriots |
Sunday, November 14, 2004 |
8:30PM |
BUF 6, NE 29 |
| Regular Season: Week 11 |
 Rams |
at |
Bills |
Sunday, November 21, 2004 |
1:00PM |
STL 17, BUF 37 |
| Regular Season: Week 12 |
Bills |
at |
 Seahawks |
Sunday, November 28, 2004 |
4:15PM |
BUF 38, SEA 9 |
| Regular Season: Week 13 |
Bills |
at |
Dolphins |
Sunday, December 5, 2004 |
1:00PM |
BUF 42, MIA 32 |
| Regular Season: Week 14 |
 Browns |
at |
Bills |
Sunday, December 12, 2004 |
1:00PM |
CLE 7, BUF 37 |
| Regular Season: Week 15 |
Bills |
at |
 Bengals |
Sunday, December 19, 2004 |
1:00PM |
BUF 33, CIN 17 |
| Regular Season: Week 16 |
Bills |
at |
 49ers |
Sunday, December 26, 2004 |
4:05PM |
BUF 41, SF 7 |
| Regular Season: Week 17 |
 Steelers |
at |
Bills |
Sunday, January 2, 2005 |
1:00PM |
PIT 29, BUF 24 |