| Regular Season: Week 1 |
 Chargers |
at |
 Browns |
Monday, September 7, 1981 |
3:00PM |
SD 44, CLE 14 |
| Regular Season: Week 2 |
 Lions |
at |
Chargers |
Sunday, September 13, 1981 |
3:00PM |
DET 23, SD 28 |
| Regular Season: Week 3 |
Chargers |
at |
 Chiefs |
Sunday, September 20, 1981 |
3:00PM |
SD 42, KC 31 |
| Regular Season: Week 4 |
Chargers |
at |
 Broncos |
Sunday, September 27, 1981 |
3:00PM |
SD 24, DEN 42 |
| Regular Season: Week 5 |
 Seahawks |
at |
Chargers |
Sunday, October 4, 1981 |
3:00PM |
SEA 10, SD 24 |
| Regular Season: Week 6 |
 Vikings |
at |
Chargers |
Sunday, October 11, 1981 |
3:00PM |
MIN 33, SD 31 |
| Regular Season: Week 7 |
Chargers |
at |
 Colts |
Sunday, October 18, 1981 |
3:00PM |
SD 43, BAL 14 |
| Regular Season: Week 8 |
Chargers |
at |
 Bears |
Sunday, October 25, 1981 |
2:00PM |
SD 17, CHI 20 |
| Regular Season: Week 9 |
Chiefs |
at |
Chargers |
Sunday, November 1, 1981 |
3:00PM |
KC 20, SD 22 |
| Regular Season: Week 10 |
 Bengals |
at |
Chargers |
Sunday, November 8, 1981 |
3:00PM |
CIN 40, SD 17 |
| Regular Season: Week 11 |
Chargers |
at |
Seahawks |
Monday, November 16, 1981 |
3:00PM |
SD 23, SEA 44 |
| Regular Season: Week 12 |
Chargers |
at |
 Raiders |
Sunday, November 22, 1981 |
3:00PM |
SD 55, OAK 21 |
| Regular Season: Week 13 |
Broncos |
at |
Chargers |
Sunday, November 29, 1981 |
3:00PM |
DEN 17, SD 34 |
| Regular Season: Week 14 |
 Bills |
at |
Chargers |
Sunday, December 6, 1981 |
3:00PM |
BUF 28, SD 27 |
| Regular Season: Week 15 |
Chargers |
at |
 Buccaneers |
Sunday, December 13, 1981 |
3:00PM |
SD 24, TB 23 |
| Regular Season: Week 16 |
Raiders |
at |
Chargers |
Monday, December 21, 1981 |
3:00PM |
OAK 10, SD 23 |
| Divisional Playoffs: Week 18 |
Chargers |
at |
 Dolphins |
Saturday, January 2, 1982 |
3:00PM |
SD 41, MIA 38 |
| Conference Championship: Week 19 |
Chargers |
at |
Bengals |
Sunday, January 10, 1982 |
3:00PM |
SD 7, CIN 27 |