| Regular Season: Week 1 |
 Colts |
at |
 Patriots |
Sunday, September 6, 1981 |
3:00PM |
BAL 29, NE 28 |
| Regular Season: Week 2 |
 Bills |
at |
Colts |
Sunday, September 13, 1981 |
3:00PM |
BUF 35, BAL 3 |
| Regular Season: Week 3 |
Colts |
at |
 Broncos |
Sunday, September 20, 1981 |
3:00PM |
BAL 10, DEN 28 |
| Regular Season: Week 4 |
 Dolphins |
at |
Colts |
Sunday, September 27, 1981 |
3:00PM |
MIA 31, BAL 28 |
| Regular Season: Week 5 |
Colts |
at |
Bills |
Sunday, October 4, 1981 |
3:00PM |
BAL 17, BUF 23 |
| Regular Season: Week 6 |
 Bengals |
at |
Colts |
Sunday, October 11, 1981 |
3:00PM |
CIN 41, BAL 19 |
| Regular Season: Week 7 |
 Chargers |
at |
Colts |
Sunday, October 18, 1981 |
3:00PM |
SD 43, BAL 14 |
| Regular Season: Week 8 |
Colts |
at |
 Browns |
Sunday, October 25, 1981 |
2:00PM |
BAL 28, CLE 42 |
| Regular Season: Week 9 |
Colts |
at |
Dolphins |
Sunday, November 1, 1981 |
3:00PM |
BAL 10, MIA 27 |
| Regular Season: Week 10 |
 Jets |
at |
Colts |
Sunday, November 8, 1981 |
3:00PM |
NYJ 41, BAL 14 |
| Regular Season: Week 11 |
Colts |
at |
 Eagles |
Sunday, November 15, 1981 |
3:00PM |
BAL 13, PHI 38 |
| Regular Season: Week 12 |
 Cardinals |
at |
Colts |
Sunday, November 22, 1981 |
3:00PM |
STL 35, BAL 24 |
| Regular Season: Week 13 |
Colts |
at |
Jets |
Sunday, November 29, 1981 |
3:00PM |
BAL 0, NYJ 25 |
| Regular Season: Week 14 |
 Cowboys |
at |
Colts |
Sunday, December 6, 1981 |
3:00PM |
DAL 37, BAL 13 |
| Regular Season: Week 15 |
Colts |
at |
 Redskins |
Sunday, December 13, 1981 |
3:00PM |
BAL 14, WAS 38 |
| Regular Season: Week 16 |
Patriots |
at |
Colts |
Sunday, December 20, 1981 |
3:00PM |
NE 21, BAL 23 |