| Regular Season: Week 1 |
 Colts |
at |
 Chargers |
Sunday, September 8, 2019 |
4:05PM |
IND 24, LAC 30 |
| Regular Season: Week 2 |
Colts |
at |
 Titans |
Sunday, September 15, 2019 |
1:00PM |
IND 19, TEN 17 |
| Regular Season: Week 3 |
 Falcons |
at |
Colts |
Sunday, September 22, 2019 |
1:00PM |
ATL 24, IND 27 |
| Regular Season: Week 4 |
 Raiders |
at |
Colts |
Sunday, September 29, 2019 |
1:00PM |
OAK 31, IND 24 |
| Regular Season: Week 5 |
Colts |
at |
 Chiefs |
Sunday, October 6, 2019 |
8:20PM |
IND 19, KC 13 |
| Regular Season: Week 7 |
 Texans |
at |
Colts |
Sunday, October 20, 2019 |
1:00PM |
HOU 23, IND 30 |
| Regular Season: Week 8 |
 Broncos |
at |
Colts |
Sunday, October 27, 2019 |
1:00PM |
DEN 13, IND 15 |
| Regular Season: Week 9 |
Colts |
at |
 Steelers |
Sunday, November 3, 2019 |
1:00PM |
IND 24, PIT 26 |
| Regular Season: Week 10 |
 Dolphins |
at |
Colts |
Sunday, November 10, 2019 |
4:05PM |
MIA 16, IND 12 |
| Regular Season: Week 11 |
 Jaguars |
at |
Colts |
Sunday, November 17, 2019 |
1:00PM |
JAX 13, IND 33 |
| Regular Season: Week 12 |
Colts |
at |
Texans |
Thursday, November 21, 2019 |
8:20PM |
IND 17, HOU 20 |
| Regular Season: Week 13 |
Titans |
at |
Colts |
Sunday, December 1, 2019 |
1:00PM |
TEN 31, IND 17 |
| Regular Season: Week 14 |
Colts |
at |
 Buccaneers |
Sunday, December 8, 2019 |
1:00PM |
IND 35, TB 38 |
| Regular Season: Week 15 |
Colts |
at |
 Saints |
Monday, December 16, 2019 |
8:15PM |
IND 7, NO 34 |
| Regular Season: Week 16 |
 Panthers |
at |
Colts |
Sunday, December 22, 2019 |
1:00PM |
CAR 6, IND 38 |
| Regular Season: Week 17 |
Colts |
at |
Jaguars |
Sunday, December 29, 2019 |
4:25PM |
IND 20, JAX 38 |