| Regular Season: Week 1 |
 Bears |
at |
 Lions |
Sunday, September 11, 1966 |
3:00PM |
CHI 3, DET 14 |
| Regular Season: Week 2 |
Lions |
at |
 Steelers |
Sunday, September 18, 1966 |
3:00PM |
DET 3, PIT 17 |
| Regular Season: Week 3 |
 Falcons |
at |
Lions |
Sunday, September 25, 1966 |
3:00PM |
ATL 10, DET 28 |
| Regular Season: Week 4 |
Lions |
at |
 Packers |
Sunday, October 2, 1966 |
3:00PM |
DET 14, GB 23 |
| Regular Season: Week 5 |
 Rams |
at |
Lions |
Sunday, October 9, 1966 |
3:00PM |
LA 14, DET 7 |
| Regular Season: Week 6 |
Lions |
at |
 Colts |
Sunday, October 16, 1966 |
3:00PM |
DET 14, BAL 45 |
| Regular Season: Week 7 |
Lions |
at |
 49ers |
Sunday, October 23, 1966 |
3:00PM |
DET 24, SF 27 |
| Regular Season: Week 8 |
Packers |
at |
Lions |
Sunday, October 30, 1966 |
2:00PM |
GB 31, DET 7 |
| Regular Season: Week 9 |
Lions |
at |
Bears |
Sunday, November 6, 1966 |
3:00PM |
DET 10, CHI 10 |
| Regular Season: Week 10 |
Lions |
at |
 Vikings |
Sunday, November 13, 1966 |
3:00PM |
DET 32, MIN 31 |
| Regular Season: Week 11 |
Colts |
at |
Lions |
Sunday, November 20, 1966 |
3:00PM |
BAL 14, DET 20 |
| Regular Season: Week 12 |
49ers |
at |
Lions |
Thursday, November 24, 1966 |
3:00PM |
SF 41, DET 14 |
| Regular Season: Week 13 |
Lions |
at |
Rams |
Sunday, December 4, 1966 |
3:00PM |
DET 3, LA 23 |
| Regular Season: Week 14 |
Vikings |
at |
Lions |
Sunday, December 11, 1966 |
3:00PM |
MIN 28, DET 16 |