| Regular Season: Week 1 |
 Lions |
at |
 Packers |
Sunday, September 21, 1975 |
3:00PM |
DET 30, GB 16 |
| Regular Season: Week 2 |
Lions |
at |
 Falcons |
Sunday, September 28, 1975 |
3:00PM |
DET 17, ATL 14 |
| Regular Season: Week 3 |
 Cowboys |
at |
Lions |
Monday, October 6, 1975 |
3:00PM |
DAL 36, DET 10 |
| Regular Season: Week 4 |
 Bears |
at |
Lions |
Sunday, October 12, 1975 |
3:00PM |
CHI 7, DET 27 |
| Regular Season: Week 5 |
Lions |
at |
 Vikings |
Sunday, October 19, 1975 |
3:00PM |
DET 19, MIN 25 |
| Regular Season: Week 6 |
Lions |
at |
 Oilers |
Sunday, October 26, 1975 |
2:00PM |
DET 8, HOU 24 |
| Regular Season: Week 7 |
Lions |
at |
 49ers |
Sunday, November 2, 1975 |
3:00PM |
DET 28, SF 17 |
| Regular Season: Week 8 |
 Browns |
at |
Lions |
Sunday, November 9, 1975 |
3:00PM |
CLE 10, DET 21 |
| Regular Season: Week 9 |
Packers |
at |
Lions |
Sunday, November 16, 1975 |
3:00PM |
GB 10, DET 13 |
| Regular Season: Week 10 |
Lions |
at |
 Chiefs |
Sunday, November 23, 1975 |
3:00PM |
DET 21, KC 24 |
| Regular Season: Week 11 |
 Rams |
at |
Lions |
Thursday, November 27, 1975 |
3:00PM |
LA 20, DET 0 |
| Regular Season: Week 12 |
Lions |
at |
Bears |
Sunday, December 7, 1975 |
3:00PM |
DET 21, CHI 25 |
| Regular Season: Week 13 |
Vikings |
at |
Lions |
Sunday, December 14, 1975 |
3:00PM |
MIN 10, DET 17 |
| Regular Season: Week 14 |
 Cardinals |
at |
Lions |
Sunday, December 21, 1975 |
3:00PM |
STL 24, DET 13 |