| Regular Season: Week 1 |
 Lions |
at |
 Rams |
Sunday, September 7, 1980 |
3:00PM |
DET 41, LA 20 |
| Regular Season: Week 2 |
Lions |
at |
 Packers |
Sunday, September 14, 1980 |
3:00PM |
DET 29, GB 7 |
| Regular Season: Week 3 |
 Cardinals |
at |
Lions |
Sunday, September 21, 1980 |
3:00PM |
STL 7, DET 20 |
| Regular Season: Week 4 |
 Vikings |
at |
Lions |
Sunday, September 28, 1980 |
3:00PM |
MIN 7, DET 27 |
| Regular Season: Week 5 |
Lions |
at |
 Falcons |
Sunday, October 5, 1980 |
3:00PM |
DET 28, ATL 43 |
| Regular Season: Week 6 |
 Saints |
at |
Lions |
Sunday, October 12, 1980 |
3:00PM |
NO 13, DET 24 |
| Regular Season: Week 7 |
Lions |
at |
 Bears |
Sunday, October 19, 1980 |
3:00PM |
DET 7, CHI 24 |
| Regular Season: Week 8 |
Lions |
at |
 Chiefs |
Sunday, October 26, 1980 |
2:00PM |
DET 17, KC 20 |
| Regular Season: Week 9 |
 49ers |
at |
Lions |
Sunday, November 2, 1980 |
3:00PM |
SF 13, DET 17 |
| Regular Season: Week 10 |
Lions |
at |
Vikings |
Sunday, November 9, 1980 |
3:00PM |
DET 0, MIN 34 |
| Regular Season: Week 11 |
 Colts |
at |
Lions |
Sunday, November 16, 1980 |
3:00PM |
BAL 10, DET 9 |
| Regular Season: Week 12 |
Lions |
at |
 Buccaneers |
Sunday, November 23, 1980 |
3:00PM |
DET 24, TB 10 |
| Regular Season: Week 13 |
Bears |
at |
Lions |
Thursday, November 27, 1980 |
3:00PM |
CHI 23, DET 17 |
| Regular Season: Week 14 |
Lions |
at |
Cardinals |
Sunday, December 7, 1980 |
3:00PM |
DET 23, STL 24 |
| Regular Season: Week 15 |
Buccaneers |
at |
Lions |
Sunday, December 14, 1980 |
3:00PM |
TB 14, DET 27 |
| Regular Season: Week 16 |
Packers |
at |
Lions |
Sunday, December 21, 1980 |
3:00PM |
GB 3, DET 24 |