| Regular Season: Week 1 |
 Lions |
at |
 Colts |
Sunday, September 11, 2016 |
4:25PM |
DET 39, IND 35 |
| Regular Season: Week 2 |
 Titans |
at |
Lions |
Sunday, September 18, 2016 |
1:00PM |
TEN 16, DET 15 |
| Regular Season: Week 3 |
Lions |
at |
 Packers |
Sunday, September 25, 2016 |
1:00PM |
DET 27, GB 34 |
| Regular Season: Week 4 |
Lions |
at |
 Bears |
Sunday, October 2, 2016 |
1:00PM |
DET 14, CHI 17 |
| Regular Season: Week 5 |
 Eagles |
at |
Lions |
Sunday, October 9, 2016 |
1:00PM |
PHI 23, DET 24 |
| Regular Season: Week 6 |
 Rams |
at |
Lions |
Sunday, October 16, 2016 |
1:00PM |
LA 28, DET 31 |
| Regular Season: Week 7 |
 Redskins |
at |
Lions |
Sunday, October 23, 2016 |
1:00PM |
WAS 17, DET 20 |
| Regular Season: Week 8 |
Lions |
at |
 Texans |
Sunday, October 30, 2016 |
1:00PM |
DET 13, HOU 20 |
| Regular Season: Week 9 |
Lions |
at |
 Vikings |
Sunday, November 6, 2016 |
1:00PM |
DET 22, MIN 16 |
| Regular Season: Week 11 |
 Jaguars |
at |
Lions |
Sunday, November 20, 2016 |
1:00PM |
JAX 19, DET 26 |
| Regular Season: Week 12 |
Vikings |
at |
Lions |
Thursday, November 24, 2016 |
12:30PM |
MIN 13, DET 16 |
| Regular Season: Week 13 |
Lions |
at |
 Saints |
Sunday, December 4, 2016 |
1:00PM |
DET 28, NO 13 |
| Regular Season: Week 14 |
Bears |
at |
Lions |
Sunday, December 11, 2016 |
1:00PM |
CHI 17, DET 20 |
| Regular Season: Week 15 |
Lions |
at |
 Giants |
Sunday, December 18, 2016 |
1:00PM |
DET 6, NYG 17 |
| Regular Season: Week 16 |
Lions |
at |
 Cowboys |
Monday, December 26, 2016 |
8:30PM |
DET 21, DAL 42 |
| Regular Season: Week 17 |
Packers |
at |
Lions |
Sunday, January 1, 2017 |
8:30PM |
GB 31, DET 24 |
| Wild Card: Week 18 |
Lions |
at |
 Seahawks |
Saturday, January 7, 2017 |
8:15PM |
DET 6, SEA 26 |