| Regular Season: Week 1 |
 Bears |
at |
 Lions |
Sunday, September 13, 2020 |
1:00PM |
CHI 27, DET 23 |
| Regular Season: Week 2 |
Lions |
at |
 Packers |
Sunday, September 20, 2020 |
1:00PM |
DET 21, GB 42 |
| Regular Season: Week 3 |
Lions |
at |
 Cardinals |
Sunday, September 27, 2020 |
4:25PM |
DET 26, ARI 23 |
| Regular Season: Week 4 |
 Saints |
at |
Lions |
Sunday, October 4, 2020 |
1:00PM |
NO 35, DET 29 |
| Regular Season: Week 6 |
Lions |
at |
 Jaguars |
Sunday, October 18, 2020 |
1:00PM |
DET 34, JAX 16 |
| Regular Season: Week 7 |
Lions |
at |
 Falcons |
Sunday, October 25, 2020 |
1:00PM |
DET 23, ATL 22 |
| Regular Season: Week 8 |
 Colts |
at |
Lions |
Sunday, November 1, 2020 |
1:00PM |
IND 41, DET 21 |
| Regular Season: Week 9 |
Lions |
at |
 Vikings |
Sunday, November 8, 2020 |
1:00PM |
DET 20, MIN 34 |
| Regular Season: Week 10 |
 Washington |
at |
Lions |
Sunday, November 15, 2020 |
1:00PM |
WAS 27, DET 30 |
| Regular Season: Week 11 |
Lions |
at |
 Panthers |
Sunday, November 22, 2020 |
1:00PM |
DET 0, CAR 20 |
| Regular Season: Week 12 |
 Texans |
at |
Lions |
Thursday, November 26, 2020 |
12:30PM |
HOU 41, DET 25 |
| Regular Season: Week 13 |
Lions |
at |
Bears |
Sunday, December 6, 2020 |
1:00PM |
DET 34, CHI 30 |
| Regular Season: Week 14 |
Packers |
at |
Lions |
Sunday, December 13, 2020 |
4:25PM |
GB 31, DET 24 |
| Regular Season: Week 15 |
Lions |
at |
 Titans |
Sunday, December 20, 2020 |
1:00PM |
DET 25, TEN 46 |
| Regular Season: Week 16 |
 Buccaneers |
at |
Lions |
Saturday, December 26, 2020 |
1:00PM |
TB 47, DET 7 |
| Regular Season: Week 17 |
Vikings |
at |
Lions |
Sunday, January 3, 2021 |
1:00PM |
MIN 37, DET 35 |