| Regular Season: Week 1 |
 Oilers |
at |
 Falcons |
Sunday, September 3, 1978 |
3:00PM |
HOU 14, ATL 20 |
| Regular Season: Week 2 |
Oilers |
at |
 Chiefs |
Sunday, September 10, 1978 |
3:00PM |
HOU 20, KC 17 |
| Regular Season: Week 3 |
 49ers |
at |
Oilers |
Sunday, September 17, 1978 |
3:00PM |
SF 19, HOU 20 |
| Regular Season: Week 4 |
 Rams |
at |
Oilers |
Sunday, September 24, 1978 |
3:00PM |
LA 10, HOU 6 |
| Regular Season: Week 5 |
Oilers |
at |
 Browns |
Sunday, October 1, 1978 |
3:00PM |
HOU 16, CLE 13 |
| Regular Season: Week 6 |
Oilers |
at |
 Raiders |
Sunday, October 8, 1978 |
3:00PM |
HOU 17, OAK 21 |
| Regular Season: Week 7 |
 Bills |
at |
Oilers |
Sunday, October 15, 1978 |
3:00PM |
BUF 10, HOU 17 |
| Regular Season: Week 8 |
Oilers |
at |
 Steelers |
Monday, October 23, 1978 |
3:00PM |
HOU 24, PIT 17 |
| Regular Season: Week 9 |
Oilers |
at |
 Bengals |
Sunday, October 29, 1978 |
2:00PM |
HOU 13, CIN 28 |
| Regular Season: Week 10 |
Browns |
at |
Oilers |
Sunday, November 5, 1978 |
3:00PM |
CLE 10, HOU 14 |
| Regular Season: Week 11 |
Oilers |
at |
 Patriots |
Sunday, November 12, 1978 |
3:00PM |
HOU 26, NE 23 |
| Regular Season: Week 12 |
 Dolphins |
at |
Oilers |
Monday, November 20, 1978 |
3:00PM |
MIA 30, HOU 35 |
| Regular Season: Week 13 |
Bengals |
at |
Oilers |
Sunday, November 26, 1978 |
3:00PM |
CIN 10, HOU 17 |
| Regular Season: Week 14 |
Steelers |
at |
Oilers |
Sunday, December 3, 1978 |
3:00PM |
PIT 13, HOU 3 |
| Regular Season: Week 15 |
Oilers |
at |
 Saints |
Sunday, December 10, 1978 |
3:00PM |
HOU 17, NO 12 |
| Regular Season: Week 16 |
 Chargers |
at |
Oilers |
Sunday, December 17, 1978 |
3:00PM |
SD 45, HOU 24 |
| Wild Card: Week 17 |
Oilers |
at |
Dolphins |
Sunday, December 24, 1978 |
3:00PM |
HOU 17, MIA 9 |
| Divisional Playoffs: Week 18 |
Oilers |
at |
Patriots |
Sunday, December 31, 1978 |
3:00PM |
HOU 31, NE 14 |
| Conference Championship: Week 19 |
Oilers |
at |
Steelers |
Sunday, January 7, 1979 |
3:00PM |
HOU 5, PIT 34 |