| Regular Season: Week 1 |
 Oilers |
at |
 Steelers |
Sunday, September 7, 1980 |
3:00PM |
HOU 17, PIT 31 |
| Regular Season: Week 2 |
Oilers |
at |
 Browns |
Monday, September 15, 1980 |
3:00PM |
HOU 16, CLE 7 |
| Regular Season: Week 3 |
 Colts |
at |
Oilers |
Sunday, September 21, 1980 |
3:00PM |
BAL 16, HOU 21 |
| Regular Season: Week 4 |
Oilers |
at |
 Bengals |
Sunday, September 28, 1980 |
3:00PM |
HOU 13, CIN 10 |
| Regular Season: Week 5 |
 Seahawks |
at |
Oilers |
Sunday, October 5, 1980 |
3:00PM |
SEA 26, HOU 7 |
| Regular Season: Week 6 |
Oilers |
at |
 Chiefs |
Sunday, October 12, 1980 |
3:00PM |
HOU 20, KC 21 |
| Regular Season: Week 7 |
 Buccaneers |
at |
Oilers |
Sunday, October 19, 1980 |
3:00PM |
TB 14, HOU 20 |
| Regular Season: Week 8 |
Bengals |
at |
Oilers |
Sunday, October 26, 1980 |
2:00PM |
CIN 3, HOU 23 |
| Regular Season: Week 9 |
Oilers |
at |
 Broncos |
Sunday, November 2, 1980 |
3:00PM |
HOU 20, DEN 16 |
| Regular Season: Week 10 |
 Patriots |
at |
Oilers |
Monday, November 10, 1980 |
3:00PM |
NE 34, HOU 38 |
| Regular Season: Week 11 |
Oilers |
at |
 Bears |
Sunday, November 16, 1980 |
3:00PM |
HOU 10, CHI 6 |
| Regular Season: Week 12 |
Oilers |
at |
 Jets |
Sunday, November 23, 1980 |
3:00PM |
HOU 28, NYJ 31 |
| Regular Season: Week 13 |
Browns |
at |
Oilers |
Sunday, November 30, 1980 |
3:00PM |
CLE 17, HOU 14 |
| Regular Season: Week 14 |
Steelers |
at |
Oilers |
Thursday, December 4, 1980 |
3:00PM |
PIT 0, HOU 6 |
| Regular Season: Week 15 |
Oilers |
at |
 Packers |
Sunday, December 14, 1980 |
3:00PM |
HOU 22, GB 3 |
| Regular Season: Week 16 |
 Vikings |
at |
Oilers |
Sunday, December 21, 1980 |
3:00PM |
MIN 16, HOU 20 |
| Wild Card: Week 17 |
Oilers |
at |
 Raiders |
Sunday, December 28, 1980 |
3:00PM |
HOU 7, OAK 27 |