| Regular Season: Week 1 |
 Oilers |
at |
 Rams |
Sunday, September 6, 1981 |
3:00PM |
HOU 27, LA 20 |
| Regular Season: Week 2 |
Oilers |
at |
 Browns |
Sunday, September 13, 1981 |
3:00PM |
HOU 9, CLE 3 |
| Regular Season: Week 3 |
 Dolphins |
at |
Oilers |
Sunday, September 20, 1981 |
3:00PM |
MIA 16, HOU 10 |
| Regular Season: Week 4 |
Oilers |
at |
 Jets |
Sunday, September 27, 1981 |
3:00PM |
HOU 17, NYJ 33 |
| Regular Season: Week 5 |
 Bengals |
at |
Oilers |
Sunday, October 4, 1981 |
3:00PM |
CIN 10, HOU 17 |
| Regular Season: Week 6 |
 Seahawks |
at |
Oilers |
Sunday, October 11, 1981 |
3:00PM |
SEA 17, HOU 35 |
| Regular Season: Week 7 |
Oilers |
at |
 Patriots |
Sunday, October 18, 1981 |
3:00PM |
HOU 10, NE 38 |
| Regular Season: Week 8 |
Oilers |
at |
 Steelers |
Monday, October 26, 1981 |
3:00PM |
HOU 13, PIT 26 |
| Regular Season: Week 9 |
Oilers |
at |
Bengals |
Sunday, November 1, 1981 |
3:00PM |
HOU 21, CIN 34 |
| Regular Season: Week 10 |
 Raiders |
at |
Oilers |
Sunday, November 8, 1981 |
3:00PM |
OAK 16, HOU 17 |
| Regular Season: Week 11 |
Oilers |
at |
 Chiefs |
Sunday, November 15, 1981 |
3:00PM |
HOU 10, KC 23 |
| Regular Season: Week 12 |
 Saints |
at |
Oilers |
Sunday, November 22, 1981 |
3:00PM |
NO 27, HOU 24 |
| Regular Season: Week 13 |
 Falcons |
at |
Oilers |
Sunday, November 29, 1981 |
3:00PM |
ATL 31, HOU 27 |
| Regular Season: Week 14 |
Browns |
at |
Oilers |
Thursday, December 3, 1981 |
3:00PM |
CLE 13, HOU 17 |
| Regular Season: Week 15 |
Oilers |
at |
 49ers |
Sunday, December 13, 1981 |
3:00PM |
HOU 6, SF 28 |
| Regular Season: Week 16 |
Steelers |
at |
Oilers |
Sunday, December 20, 1981 |
3:00PM |
PIT 20, HOU 21 |