| Regular Season: Week 1 |
 49ers |
at |
 Colts |
Sunday, September 15, 1968 |
3:00PM |
SF 10, BAL 27 |
| Regular Season: Week 2 |
 Cardinals |
at |
49ers |
Sunday, September 22, 1968 |
3:00PM |
STL 17, SF 35 |
| Regular Season: Week 3 |
 Falcons |
at |
49ers |
Sunday, September 29, 1968 |
3:00PM |
ATL 13, SF 28 |
| Regular Season: Week 4 |
49ers |
at |
 Rams |
Sunday, October 6, 1968 |
3:00PM |
SF 10, LA 24 |
| Regular Season: Week 5 |
Colts |
at |
49ers |
Sunday, October 13, 1968 |
3:00PM |
BAL 42, SF 14 |
| Regular Season: Week 6 |
49ers |
at |
 Giants |
Sunday, October 20, 1968 |
3:00PM |
SF 26, NYG 10 |
| Regular Season: Week 7 |
49ers |
at |
 Lions |
Sunday, October 27, 1968 |
2:00PM |
SF 14, DET 7 |
| Regular Season: Week 8 |
 Browns |
at |
49ers |
Sunday, November 3, 1968 |
3:00PM |
CLE 33, SF 21 |
| Regular Season: Week 9 |
49ers |
at |
 Bears |
Sunday, November 10, 1968 |
3:00PM |
SF 19, CHI 27 |
| Regular Season: Week 10 |
Rams |
at |
49ers |
Sunday, November 17, 1968 |
3:00PM |
LA 20, SF 20 |
| Regular Season: Week 11 |
49ers |
at |
 Steelers |
Sunday, November 24, 1968 |
3:00PM |
SF 45, PIT 28 |
| Regular Season: Week 12 |
 Packers |
at |
49ers |
Sunday, December 1, 1968 |
3:00PM |
GB 20, SF 27 |
| Regular Season: Week 13 |
 Vikings |
at |
49ers |
Sunday, December 8, 1968 |
3:00PM |
MIN 30, SF 20 |
| Regular Season: Week 14 |
49ers |
at |
Falcons |
Sunday, December 15, 1968 |
3:00PM |
SF 14, ATL 12 |