| Regular Season: Week 1 |
 Chargers |
at |
 49ers |
Sunday, September 17, 1972 |
3:00PM |
SD 3, SF 34 |
| Regular Season: Week 2 |
49ers |
at |
 Bills |
Sunday, September 24, 1972 |
3:00PM |
SF 20, BUF 27 |
| Regular Season: Week 3 |
49ers |
at |
 Saints |
Sunday, October 1, 1972 |
3:00PM |
SF 37, NO 2 |
| Regular Season: Week 4 |
49ers |
at |
 Rams |
Sunday, October 8, 1972 |
3:00PM |
SF 7, LA 31 |
| Regular Season: Week 5 |
 Giants |
at |
49ers |
Sunday, October 15, 1972 |
3:00PM |
NYG 23, SF 17 |
| Regular Season: Week 6 |
Saints |
at |
49ers |
Sunday, October 22, 1972 |
3:00PM |
NO 20, SF 20 |
| Regular Season: Week 7 |
49ers |
at |
 Falcons |
Sunday, October 29, 1972 |
2:00PM |
SF 49, ATL 14 |
| Regular Season: Week 8 |
49ers |
at |
 Packers |
Sunday, November 5, 1972 |
3:00PM |
SF 24, GB 34 |
| Regular Season: Week 9 |
 Colts |
at |
49ers |
Sunday, November 12, 1972 |
3:00PM |
BAL 21, SF 24 |
| Regular Season: Week 10 |
49ers |
at |
 Bears |
Sunday, November 19, 1972 |
3:00PM |
SF 34, CHI 21 |
| Regular Season: Week 11 |
49ers |
at |
 Cowboys |
Thursday, November 23, 1972 |
3:00PM |
SF 31, DAL 10 |
| Regular Season: Week 12 |
Rams |
at |
49ers |
Monday, December 4, 1972 |
3:00PM |
LA 26, SF 16 |
| Regular Season: Week 13 |
Falcons |
at |
49ers |
Sunday, December 10, 1972 |
3:00PM |
ATL 0, SF 20 |
| Regular Season: Week 14 |
 Vikings |
at |
49ers |
Saturday, December 16, 1972 |
3:00PM |
MIN 17, SF 20 |
| Divisional Playoffs: Week 15 |
Cowboys |
at |
49ers |
Saturday, December 23, 1972 |
3:00PM |
DAL 30, SF 28 |