| Regular Season: Week 1 |
 49ers |
at |
 Vikings |
Sunday, September 21, 1975 |
3:00PM |
SF 17, MIN 27 |
| Regular Season: Week 2 |
 Rams |
at |
49ers |
Sunday, September 28, 1975 |
3:00PM |
LA 23, SF 14 |
| Regular Season: Week 3 |
49ers |
at |
 Chiefs |
Sunday, October 5, 1975 |
3:00PM |
SF 20, KC 3 |
| Regular Season: Week 4 |
 Falcons |
at |
49ers |
Sunday, October 12, 1975 |
3:00PM |
ATL 17, SF 3 |
| Regular Season: Week 5 |
 Saints |
at |
49ers |
Sunday, October 19, 1975 |
3:00PM |
NO 21, SF 35 |
| Regular Season: Week 6 |
49ers |
at |
 Patriots |
Sunday, October 26, 1975 |
2:00PM |
SF 16, NE 24 |
| Regular Season: Week 7 |
 Lions |
at |
49ers |
Sunday, November 2, 1975 |
3:00PM |
DET 28, SF 17 |
| Regular Season: Week 8 |
49ers |
at |
Rams |
Sunday, November 9, 1975 |
3:00PM |
SF 24, LA 23 |
| Regular Season: Week 9 |
 Bears |
at |
49ers |
Sunday, November 16, 1975 |
3:00PM |
CHI 3, SF 31 |
| Regular Season: Week 10 |
49ers |
at |
Saints |
Sunday, November 23, 1975 |
3:00PM |
SF 16, NO 6 |
| Regular Season: Week 11 |
49ers |
at |
 Eagles |
Sunday, November 30, 1975 |
3:00PM |
SF 17, PHI 27 |
| Regular Season: Week 12 |
 Oilers |
at |
49ers |
Sunday, December 7, 1975 |
3:00PM |
HOU 27, SF 13 |
| Regular Season: Week 13 |
49ers |
at |
Falcons |
Sunday, December 14, 1975 |
3:00PM |
SF 9, ATL 31 |
| Regular Season: Week 14 |
 Giants |
at |
49ers |
Sunday, December 21, 1975 |
3:00PM |
NYG 26, SF 23 |