| Regular Season: Week 1 |
 49ers |
at |
 Browns |
Sunday, September 3, 1978 |
3:00PM |
SF 7, CLE 24 |
| Regular Season: Week 2 |
 Bears |
at |
49ers |
Sunday, September 10, 1978 |
3:00PM |
CHI 16, SF 13 |
| Regular Season: Week 3 |
49ers |
at |
 Oilers |
Sunday, September 17, 1978 |
3:00PM |
SF 19, HOU 20 |
| Regular Season: Week 4 |
49ers |
at |
 Giants |
Sunday, September 24, 1978 |
3:00PM |
SF 10, NYG 27 |
| Regular Season: Week 5 |
 Bengals |
at |
49ers |
Sunday, October 1, 1978 |
3:00PM |
CIN 12, SF 28 |
| Regular Season: Week 6 |
49ers |
at |
 Rams |
Sunday, October 8, 1978 |
3:00PM |
SF 10, LA 27 |
| Regular Season: Week 7 |
 Saints |
at |
49ers |
Sunday, October 15, 1978 |
3:00PM |
NO 14, SF 7 |
| Regular Season: Week 8 |
 Falcons |
at |
49ers |
Sunday, October 22, 1978 |
3:00PM |
ATL 20, SF 17 |
| Regular Season: Week 9 |
49ers |
at |
 Redskins |
Sunday, October 29, 1978 |
2:00PM |
SF 20, WAS 38 |
| Regular Season: Week 10 |
49ers |
at |
Falcons |
Sunday, November 5, 1978 |
3:00PM |
SF 10, ATL 21 |
| Regular Season: Week 11 |
 Cardinals |
at |
49ers |
Sunday, November 12, 1978 |
3:00PM |
STL 16, SF 10 |
| Regular Season: Week 12 |
Rams |
at |
49ers |
Sunday, November 19, 1978 |
3:00PM |
LA 31, SF 28 |
| Regular Season: Week 13 |
 Steelers |
at |
49ers |
Monday, November 27, 1978 |
3:00PM |
PIT 24, SF 7 |
| Regular Season: Week 14 |
49ers |
at |
Saints |
Sunday, December 3, 1978 |
3:00PM |
SF 13, NO 24 |
| Regular Season: Week 15 |
 Buccaneers |
at |
49ers |
Sunday, December 10, 1978 |
3:00PM |
TB 3, SF 6 |
| Regular Season: Week 16 |
49ers |
at |
 Lions |
Sunday, December 17, 1978 |
3:00PM |
SF 14, DET 33 |