| Regular Season: Week 1 |
 49ers |
at |
 Saints |
Sunday, September 7, 1980 |
3:00PM |
SF 26, NO 23 |
| Regular Season: Week 2 |
 Cardinals |
at |
49ers |
Sunday, September 14, 1980 |
3:00PM |
STL 21, SF 24 |
| Regular Season: Week 3 |
49ers |
at |
 Jets |
Sunday, September 21, 1980 |
3:00PM |
SF 37, NYJ 27 |
| Regular Season: Week 4 |
 Falcons |
at |
49ers |
Sunday, September 28, 1980 |
3:00PM |
ATL 20, SF 17 |
| Regular Season: Week 5 |
49ers |
at |
 Rams |
Sunday, October 5, 1980 |
3:00PM |
SF 26, LA 48 |
| Regular Season: Week 6 |
49ers |
at |
 Cowboys |
Sunday, October 12, 1980 |
3:00PM |
SF 14, DAL 59 |
| Regular Season: Week 7 |
Rams |
at |
49ers |
Sunday, October 19, 1980 |
3:00PM |
LA 31, SF 17 |
| Regular Season: Week 8 |
 Buccaneers |
at |
49ers |
Sunday, October 26, 1980 |
2:00PM |
TB 24, SF 23 |
| Regular Season: Week 9 |
49ers |
at |
 Lions |
Sunday, November 2, 1980 |
3:00PM |
SF 13, DET 17 |
| Regular Season: Week 10 |
49ers |
at |
 Packers |
Sunday, November 9, 1980 |
3:00PM |
SF 16, GB 23 |
| Regular Season: Week 11 |
49ers |
at |
 Dolphins |
Sunday, November 16, 1980 |
3:00PM |
SF 13, MIA 17 |
| Regular Season: Week 12 |
 Giants |
at |
49ers |
Sunday, November 23, 1980 |
3:00PM |
NYG 0, SF 12 |
| Regular Season: Week 13 |
 Patriots |
at |
49ers |
Sunday, November 30, 1980 |
3:00PM |
NE 17, SF 21 |
| Regular Season: Week 14 |
Saints |
at |
49ers |
Sunday, December 7, 1980 |
3:00PM |
NO 35, SF 38 |
| Regular Season: Week 15 |
49ers |
at |
Falcons |
Sunday, December 14, 1980 |
3:00PM |
SF 10, ATL 35 |
| Regular Season: Week 16 |
 Bills |
at |
49ers |
Sunday, December 21, 1980 |
3:00PM |
BUF 18, SF 13 |