| Regular Season: Week 1 |
 49ers |
at |
 Lions |
Sunday, September 6, 1981 |
3:00PM |
SF 17, DET 24 |
| Regular Season: Week 2 |
 Bears |
at |
49ers |
Sunday, September 13, 1981 |
3:00PM |
CHI 17, SF 28 |
| Regular Season: Week 3 |
49ers |
at |
 Falcons |
Sunday, September 20, 1981 |
3:00PM |
SF 17, ATL 34 |
| Regular Season: Week 4 |
 Saints |
at |
49ers |
Sunday, September 27, 1981 |
3:00PM |
NO 14, SF 21 |
| Regular Season: Week 5 |
49ers |
at |
 Redskins |
Sunday, October 4, 1981 |
3:00PM |
SF 30, WAS 17 |
| Regular Season: Week 6 |
 Cowboys |
at |
49ers |
Sunday, October 11, 1981 |
3:00PM |
DAL 14, SF 45 |
| Regular Season: Week 7 |
49ers |
at |
 Packers |
Sunday, October 18, 1981 |
3:00PM |
SF 13, GB 3 |
| Regular Season: Week 8 |
 Rams |
at |
49ers |
Sunday, October 25, 1981 |
2:00PM |
LA 17, SF 20 |
| Regular Season: Week 9 |
49ers |
at |
 Steelers |
Sunday, November 1, 1981 |
3:00PM |
SF 17, PIT 14 |
| Regular Season: Week 10 |
Falcons |
at |
49ers |
Sunday, November 8, 1981 |
3:00PM |
ATL 14, SF 17 |
| Regular Season: Week 11 |
 Browns |
at |
49ers |
Sunday, November 15, 1981 |
3:00PM |
CLE 15, SF 12 |
| Regular Season: Week 12 |
49ers |
at |
Rams |
Sunday, November 22, 1981 |
3:00PM |
SF 33, LA 31 |
| Regular Season: Week 13 |
 Giants |
at |
49ers |
Sunday, November 29, 1981 |
3:00PM |
NYG 10, SF 17 |
| Regular Season: Week 14 |
49ers |
at |
 Bengals |
Sunday, December 6, 1981 |
3:00PM |
SF 21, CIN 3 |
| Regular Season: Week 15 |
 Oilers |
at |
49ers |
Sunday, December 13, 1981 |
3:00PM |
HOU 6, SF 28 |
| Regular Season: Week 16 |
49ers |
at |
Saints |
Sunday, December 20, 1981 |
3:00PM |
SF 21, NO 17 |
| Divisional Playoffs: Week 18 |
Giants |
at |
49ers |
Sunday, January 3, 1982 |
3:00PM |
NYG 24, SF 38 |
| Conference Championship: Week 19 |
Cowboys |
at |
49ers |
Sunday, January 10, 1982 |
3:00PM |
DAL 27, SF 28 |
| Super Bowl: Week 20 |
49ers |
at |
Bengals |
Sunday, January 24, 1982 |
3:00PM |
SF 26, CIN 21 |