| Regular Season: Week 1 |
 49ers |
at |
 Giants |
Monday, September 2, 1991 |
3:00PM |
SF 14, NYG 16 |
| Regular Season: Week 2 |
 Chargers |
at |
49ers |
Sunday, September 8, 1991 |
3:00PM |
SD 14, SF 34 |
| Regular Season: Week 3 |
49ers |
at |
 Vikings |
Sunday, September 15, 1991 |
3:00PM |
SF 14, MIN 17 |
| Regular Season: Week 4 |
 Rams |
at |
49ers |
Sunday, September 22, 1991 |
3:00PM |
RAM 10, SF 27 |
| Regular Season: Week 5 |
49ers |
at |
 Raiders |
Sunday, September 29, 1991 |
3:00PM |
SF 6, RAI 12 |
| Regular Season: Week 7 |
 Falcons |
at |
49ers |
Sunday, October 13, 1991 |
3:00PM |
ATL 39, SF 34 |
| Regular Season: Week 8 |
 Lions |
at |
49ers |
Sunday, October 20, 1991 |
3:00PM |
DET 3, SF 35 |
| Regular Season: Week 9 |
49ers |
at |
 Eagles |
Sunday, October 27, 1991 |
2:00PM |
SF 23, PHI 7 |
| Regular Season: Week 10 |
49ers |
at |
Falcons |
Sunday, November 3, 1991 |
3:00PM |
SF 14, ATL 17 |
| Regular Season: Week 11 |
49ers |
at |
 Saints |
Sunday, November 10, 1991 |
3:00PM |
SF 3, NO 10 |
| Regular Season: Week 12 |
 Cardinals |
at |
49ers |
Sunday, November 17, 1991 |
3:00PM |
PHO 10, SF 14 |
| Regular Season: Week 13 |
49ers |
at |
Rams |
Monday, November 25, 1991 |
3:00PM |
SF 33, RAM 10 |
| Regular Season: Week 14 |
Saints |
at |
49ers |
Sunday, December 1, 1991 |
3:00PM |
NO 24, SF 38 |
| Regular Season: Week 15 |
49ers |
at |
 Seahawks |
Sunday, December 8, 1991 |
3:00PM |
SF 24, SEA 22 |
| Regular Season: Week 16 |
 Chiefs |
at |
49ers |
Saturday, December 14, 1991 |
3:00PM |
KC 14, SF 28 |
| Regular Season: Week 17 |
 Bears |
at |
49ers |
Monday, December 23, 1991 |
3:00PM |
CHI 14, SF 52 |