| Regular Season: Week 1 |
 Rams |
at |
 49ers |
Sunday, September 11, 2005 |
4:15PM |
STL 25, SF 28 |
| Regular Season: Week 2 |
49ers |
at |
 Eagles |
Sunday, September 18, 2005 |
1:00PM |
SF 3, PHI 42 |
| Regular Season: Week 3 |
 Cowboys |
at |
49ers |
Sunday, September 25, 2005 |
4:05PM |
DAL 34, SF 31 |
| Regular Season: Week 4 |
49ers |
at |
 Cardinals |
Sunday, October 2, 2005 |
8:30PM |
SF 14, ARI 31 |
| Regular Season: Week 5 |
 Colts |
at |
49ers |
Sunday, October 9, 2005 |
4:05PM |
IND 28, SF 3 |
| Regular Season: Week 7 |
49ers |
at |
 Redskins |
Sunday, October 23, 2005 |
1:00PM |
SF 17, WAS 52 |
| Regular Season: Week 8 |
 Buccaneers |
at |
49ers |
Sunday, October 30, 2005 |
4:15PM |
TB 10, SF 15 |
| Regular Season: Week 9 |
 Giants |
at |
49ers |
Sunday, November 6, 2005 |
4:05PM |
NYG 24, SF 6 |
| Regular Season: Week 10 |
49ers |
at |
 Bears |
Sunday, November 13, 2005 |
1:00PM |
SF 9, CHI 17 |
| Regular Season: Week 11 |
 Seahawks |
at |
49ers |
Sunday, November 20, 2005 |
4:05PM |
SEA 27, SF 25 |
| Regular Season: Week 12 |
49ers |
at |
 Titans |
Sunday, November 27, 2005 |
1:00PM |
SF 22, TEN 33 |
| Regular Season: Week 13 |
Cardinals |
at |
49ers |
Sunday, December 4, 2005 |
4:05PM |
ARI 17, SF 10 |
| Regular Season: Week 14 |
49ers |
at |
Seahawks |
Sunday, December 11, 2005 |
4:05PM |
SF 3, SEA 41 |
| Regular Season: Week 15 |
49ers |
at |
 Jaguars |
Sunday, December 18, 2005 |
1:00PM |
SF 9, JAC 10 |
| Regular Season: Week 16 |
49ers |
at |
Rams |
Saturday, December 24, 2005 |
1:00PM |
SF 24, STL 20 |
| Regular Season: Week 17 |
 Texans |
at |
49ers |
Sunday, January 1, 2006 |
4:05PM |
HOU 17, SF 20 |