| Regular Season: Week 1 |
 Vikings |
at |
 49ers |
Monday, September 14, 2015 |
10:20PM |
MIN 3, SF 20 |
| Regular Season: Week 2 |
49ers |
at |
 Steelers |
Sunday, September 20, 2015 |
1:00PM |
SF 18, PIT 43 |
| Regular Season: Week 3 |
49ers |
at |
 Cardinals |
Sunday, September 27, 2015 |
4:05PM |
SF 7, ARI 47 |
| Regular Season: Week 4 |
 Packers |
at |
49ers |
Sunday, October 4, 2015 |
4:25PM |
GB 17, SF 3 |
| Regular Season: Week 5 |
49ers |
at |
 Giants |
Sunday, October 11, 2015 |
8:30PM |
SF 27, NYG 30 |
| Regular Season: Week 6 |
 Ravens |
at |
49ers |
Sunday, October 18, 2015 |
4:25PM |
BAL 20, SF 25 |
| Regular Season: Week 7 |
 Seahawks |
at |
49ers |
Thursday, October 22, 2015 |
8:25PM |
SEA 20, SF 3 |
| Regular Season: Week 8 |
49ers |
at |
 Rams |
Sunday, November 1, 2015 |
1:00PM |
SF 6, STL 27 |
| Regular Season: Week 9 |
 Falcons |
at |
49ers |
Sunday, November 8, 2015 |
4:05PM |
ATL 16, SF 17 |
| Regular Season: Week 11 |
49ers |
at |
Seahawks |
Sunday, November 22, 2015 |
4:25PM |
SF 13, SEA 29 |
| Regular Season: Week 12 |
Cardinals |
at |
49ers |
Sunday, November 29, 2015 |
4:05PM |
ARI 19, SF 13 |
| Regular Season: Week 13 |
49ers |
at |
 Bears |
Sunday, December 6, 2015 |
1:00PM |
SF 26, CHI 20 |
| Regular Season: Week 14 |
49ers |
at |
 Browns |
Sunday, December 13, 2015 |
1:00PM |
SF 10, CLE 24 |
| Regular Season: Week 15 |
 Bengals |
at |
49ers |
Sunday, December 20, 2015 |
4:25PM |
CIN 24, SF 14 |
| Regular Season: Week 16 |
49ers |
at |
 Lions |
Sunday, December 27, 2015 |
1:00PM |
SF 17, DET 32 |
| Regular Season: Week 17 |
Rams |
at |
49ers |
Sunday, January 3, 2016 |
4:25PM |
STL 16, SF 19 |