| Regular Season: Week 1 |
 Rams |
at |
 49ers |
Monday, September 12, 2016 |
10:20PM |
LA 0, SF 28 |
| Regular Season: Week 2 |
49ers |
at |
 Panthers |
Sunday, September 18, 2016 |
1:00PM |
SF 27, CAR 46 |
| Regular Season: Week 3 |
49ers |
at |
 Seahawks |
Sunday, September 25, 2016 |
4:05PM |
SF 18, SEA 37 |
| Regular Season: Week 4 |
 Cowboys |
at |
49ers |
Sunday, October 2, 2016 |
4:25PM |
DAL 24, SF 17 |
| Regular Season: Week 5 |
 Cardinals |
at |
49ers |
Thursday, October 6, 2016 |
8:25PM |
ARI 33, SF 21 |
| Regular Season: Week 6 |
49ers |
at |
 Bills |
Sunday, October 16, 2016 |
1:00PM |
SF 16, BUF 45 |
| Regular Season: Week 7 |
 Buccaneers |
at |
49ers |
Sunday, October 23, 2016 |
4:05PM |
TB 34, SF 17 |
| Regular Season: Week 9 |
 Saints |
at |
49ers |
Sunday, November 6, 2016 |
4:05PM |
NO 41, SF 23 |
| Regular Season: Week 10 |
49ers |
at |
Cardinals |
Sunday, November 13, 2016 |
4:25PM |
SF 20, ARI 23 |
| Regular Season: Week 11 |
 Patriots |
at |
49ers |
Sunday, November 20, 2016 |
4:25PM |
NE 30, SF 17 |
| Regular Season: Week 12 |
49ers |
at |
 Dolphins |
Sunday, November 27, 2016 |
1:00PM |
SF 24, MIA 31 |
| Regular Season: Week 13 |
49ers |
at |
 Bears |
Sunday, December 4, 2016 |
1:00PM |
SF 6, CHI 26 |
| Regular Season: Week 14 |
 Jets |
at |
49ers |
Sunday, December 11, 2016 |
4:05PM |
NYJ 23, SF 17 |
| Regular Season: Week 15 |
49ers |
at |
 Falcons |
Sunday, December 18, 2016 |
4:05PM |
SF 13, ATL 41 |
| Regular Season: Week 16 |
49ers |
at |
Rams |
Saturday, December 24, 2016 |
4:25PM |
SF 22, LA 21 |
| Regular Season: Week 17 |
Seahawks |
at |
49ers |
Sunday, January 1, 2017 |
4:25PM |
SEA 25, SF 23 |