| Regular Season: Week 1 |
 Panthers |
at |
 49ers |
Sunday, September 10, 2017 |
4:25PM |
CAR 23, SF 3 |
| Regular Season: Week 2 |
49ers |
at |
 Seahawks |
Sunday, September 17, 2017 |
4:25PM |
SF 9, SEA 12 |
| Regular Season: Week 3 |
 Rams |
at |
49ers |
Thursday, September 21, 2017 |
8:25PM |
LA 41, SF 39 |
| Regular Season: Week 4 |
49ers |
at |
 Cardinals |
Sunday, October 1, 2017 |
4:05PM |
SF 15, ARI 18 |
| Regular Season: Week 5 |
49ers |
at |
 Colts |
Sunday, October 8, 2017 |
1:00PM |
SF 23, IND 26 |
| Regular Season: Week 6 |
49ers |
at |
 Redskins |
Sunday, October 15, 2017 |
1:00PM |
SF 24, WAS 26 |
| Regular Season: Week 7 |
 Cowboys |
at |
49ers |
Sunday, October 22, 2017 |
4:05PM |
DAL 40, SF 10 |
| Regular Season: Week 8 |
49ers |
at |
 Eagles |
Sunday, October 29, 2017 |
1:00PM |
SF 10, PHI 33 |
| Regular Season: Week 9 |
Cardinals |
at |
49ers |
Sunday, November 5, 2017 |
4:05PM |
ARI 20, SF 10 |
| Regular Season: Week 10 |
 Giants |
at |
49ers |
Sunday, November 12, 2017 |
4:25PM |
NYG 21, SF 31 |
| Regular Season: Week 12 |
Seahawks |
at |
49ers |
Sunday, November 26, 2017 |
4:05PM |
SEA 24, SF 13 |
| Regular Season: Week 13 |
49ers |
at |
 Bears |
Sunday, December 3, 2017 |
1:00PM |
SF 15, CHI 14 |
| Regular Season: Week 14 |
49ers |
at |
 Texans |
Sunday, December 10, 2017 |
1:00PM |
SF 26, HOU 16 |
| Regular Season: Week 15 |
 Titans |
at |
49ers |
Sunday, December 17, 2017 |
4:25PM |
TEN 23, SF 25 |
| Regular Season: Week 16 |
 Jaguars |
at |
49ers |
Sunday, December 24, 2017 |
4:05PM |
JAX 33, SF 44 |
| Regular Season: Week 17 |
49ers |
at |
Rams |
Sunday, December 31, 2017 |
4:25PM |
SF 34, LA 13 |