| Regular Season: Week 1 |
 49ers |
at |
 Vikings |
Sunday, September 9, 2018 |
1:00PM |
SF 16, MIN 24 |
| Regular Season: Week 2 |
 Lions |
at |
49ers |
Sunday, September 16, 2018 |
4:05PM |
DET 27, SF 30 |
| Regular Season: Week 3 |
49ers |
at |
 Chiefs |
Sunday, September 23, 2018 |
1:00PM |
SF 27, KC 38 |
| Regular Season: Week 4 |
49ers |
at |
 Chargers |
Sunday, September 30, 2018 |
4:25PM |
SF 27, LAC 29 |
| Regular Season: Week 5 |
 Cardinals |
at |
49ers |
Sunday, October 7, 2018 |
4:25PM |
ARI 28, SF 18 |
| Regular Season: Week 6 |
49ers |
at |
 Packers |
Monday, October 15, 2018 |
8:15PM |
SF 30, GB 33 |
| Regular Season: Week 7 |
 Rams |
at |
49ers |
Sunday, October 21, 2018 |
4:25PM |
LA 39, SF 10 |
| Regular Season: Week 8 |
49ers |
at |
Cardinals |
Sunday, October 28, 2018 |
4:25PM |
SF 15, ARI 18 |
| Regular Season: Week 9 |
 Raiders |
at |
49ers |
Thursday, November 1, 2018 |
8:20PM |
OAK 3, SF 34 |
| Regular Season: Week 10 |
 Giants |
at |
49ers |
Monday, November 12, 2018 |
8:15PM |
NYG 27, SF 23 |
| Regular Season: Week 12 |
49ers |
at |
 Buccaneers |
Sunday, November 25, 2018 |
1:00PM |
SF 9, TB 27 |
| Regular Season: Week 13 |
49ers |
at |
 Seahawks |
Sunday, December 2, 2018 |
4:25PM |
SF 16, SEA 43 |
| Regular Season: Week 14 |
 Broncos |
at |
49ers |
Sunday, December 9, 2018 |
4:05PM |
DEN 14, SF 20 |
| Regular Season: Week 15 |
Seahawks |
at |
49ers |
Sunday, December 16, 2018 |
4:05PM |
SEA 23, SF 26 |
| Regular Season: Week 16 |
 Bears |
at |
49ers |
Sunday, December 23, 2018 |
4:05PM |
CHI 14, SF 9 |
| Regular Season: Week 17 |
49ers |
at |
Rams |
Sunday, December 30, 2018 |
4:25PM |
SF 32, LA 48 |