| Regular Season: Week 1 |
 49ers |
at |
 Lions |
Sunday, September 12, 2021 |
1:00PM |
SF 41, DET 33 |
| Regular Season: Week 2 |
49ers |
at |
 Eagles |
Sunday, September 19, 2021 |
1:00PM |
SF 17, PHI 11 |
| Regular Season: Week 3 |
 Packers |
at |
49ers |
Sunday, September 26, 2021 |
8:20PM |
GB 30, SF 28 |
| Regular Season: Week 4 |
 Seahawks |
at |
49ers |
Sunday, October 3, 2021 |
4:05PM |
SEA 28, SF 21 |
| Regular Season: Week 5 |
49ers |
at |
 Cardinals |
Sunday, October 10, 2021 |
4:25PM |
SF 10, ARI 17 |
| Regular Season: Week 7 |
 Colts |
at |
49ers |
Sunday, October 24, 2021 |
8:20PM |
IND 30, SF 18 |
| Regular Season: Week 8 |
49ers |
at |
 Bears |
Sunday, October 31, 2021 |
1:00PM |
SF 33, CHI 22 |
| Regular Season: Week 9 |
Cardinals |
at |
49ers |
Sunday, November 7, 2021 |
4:25PM |
ARI 31, SF 17 |
| Regular Season: Week 10 |
 Rams |
at |
49ers |
Monday, November 15, 2021 |
8:15PM |
LAR 10, SF 31 |
| Regular Season: Week 11 |
49ers |
at |
 Jaguars |
Sunday, November 21, 2021 |
1:00PM |
SF 30, JAX 10 |
| Regular Season: Week 12 |
 Vikings |
at |
49ers |
Sunday, November 28, 2021 |
4:25PM |
MIN 26, SF 34 |
| Regular Season: Week 13 |
49ers |
at |
Seahawks |
Sunday, December 5, 2021 |
8:20PM |
SF 23, SEA 30 |
| Regular Season: Week 14 |
49ers |
at |
 Bengals |
Sunday, December 12, 2021 |
1:00PM |
SF 26, CIN 23 |
| Regular Season: Week 15 |
 Falcons |
at |
49ers |
Sunday, December 19, 2021 |
4:05PM |
ATL 13, SF 31 |
| Regular Season: Week 16 |
49ers |
at |
 Titans |
Thursday, December 23, 2021 |
8:20PM |
SF 17, TEN 20 |
| Regular Season: Week 17 |
 Texans |
at |
49ers |
Sunday, January 2, 2022 |
4:05PM |
HOU 7, SF 23 |
| Regular Season: Week 18 |
49ers |
at |
Rams |
Sunday, January 9, 2022 |
4:25PM |
SF 27, LAR 24 |