| Regular Season: Week 1 |
 Buccaneers |
at |
 Bengals |
Sunday, September 7, 1980 |
3:00PM |
TB 17, CIN 12 |
| Regular Season: Week 2 |
Bengals |
at |
 Dolphins |
Sunday, September 14, 1980 |
3:00PM |
CIN 16, MIA 17 |
| Regular Season: Week 3 |
 Steelers |
at |
Bengals |
Sunday, September 21, 1980 |
3:00PM |
PIT 28, CIN 30 |
| Regular Season: Week 4 |
 Oilers |
at |
Bengals |
Sunday, September 28, 1980 |
3:00PM |
HOU 13, CIN 10 |
| Regular Season: Week 5 |
Bengals |
at |
 Packers |
Sunday, October 5, 1980 |
3:00PM |
CIN 9, GB 14 |
| Regular Season: Week 6 |
Bengals |
at |
Steelers |
Sunday, October 12, 1980 |
3:00PM |
CIN 17, PIT 16 |
| Regular Season: Week 7 |
 Vikings |
at |
Bengals |
Sunday, October 19, 1980 |
3:00PM |
MIN 0, CIN 14 |
| Regular Season: Week 8 |
Bengals |
at |
Oilers |
Sunday, October 26, 1980 |
2:00PM |
CIN 3, HOU 23 |
| Regular Season: Week 9 |
 Chargers |
at |
Bengals |
Sunday, November 2, 1980 |
3:00PM |
SD 31, CIN 14 |
| Regular Season: Week 10 |
Bengals |
at |
 Raiders |
Sunday, November 9, 1980 |
3:00PM |
CIN 17, OAK 28 |
| Regular Season: Week 11 |
 Bills |
at |
Bengals |
Sunday, November 16, 1980 |
3:00PM |
BUF 14, CIN 0 |
| Regular Season: Week 12 |
Bengals |
at |
 Browns |
Sunday, November 23, 1980 |
3:00PM |
CIN 7, CLE 31 |
| Regular Season: Week 13 |
Bengals |
at |
 Chiefs |
Sunday, November 30, 1980 |
3:00PM |
CIN 20, KC 6 |
| Regular Season: Week 14 |
 Colts |
at |
Bengals |
Sunday, December 7, 1980 |
3:00PM |
BAL 33, CIN 34 |
| Regular Season: Week 15 |
Bengals |
at |
 Bears |
Sunday, December 14, 1980 |
3:00PM |
CIN 17, CHI 14 |
| Regular Season: Week 16 |
Browns |
at |
Bengals |
Sunday, December 21, 1980 |
3:00PM |
CLE 27, CIN 24 |