| Regular Season: Week 1 |
 Vikings |
at |
 Bengals |
Sunday, September 12, 2021 |
1:00PM |
MIN 24, CIN 27 |
| Regular Season: Week 2 |
Bengals |
at |
 Bears |
Sunday, September 19, 2021 |
1:00PM |
CIN 17, CHI 20 |
| Regular Season: Week 3 |
Bengals |
at |
 Steelers |
Sunday, September 26, 2021 |
1:00PM |
CIN 24, PIT 10 |
| Regular Season: Week 4 |
 Jaguars |
at |
Bengals |
Thursday, September 30, 2021 |
8:20PM |
JAX 21, CIN 24 |
| Regular Season: Week 5 |
 Packers |
at |
Bengals |
Sunday, October 10, 2021 |
1:00PM |
GB 25, CIN 22 |
| Regular Season: Week 6 |
Bengals |
at |
 Lions |
Sunday, October 17, 2021 |
1:00PM |
CIN 34, DET 11 |
| Regular Season: Week 7 |
Bengals |
at |
 Ravens |
Sunday, October 24, 2021 |
1:00PM |
CIN 41, BAL 17 |
| Regular Season: Week 8 |
Bengals |
at |
 Jets |
Sunday, October 31, 2021 |
1:00PM |
CIN 31, NYJ 34 |
| Regular Season: Week 9 |
 Browns |
at |
Bengals |
Sunday, November 7, 2021 |
1:00PM |
CLE 41, CIN 16 |
| Regular Season: Week 11 |
Bengals |
at |
 Raiders |
Sunday, November 21, 2021 |
4:05PM |
CIN 32, LV 13 |
| Regular Season: Week 12 |
Steelers |
at |
Bengals |
Sunday, November 28, 2021 |
1:00PM |
PIT 10, CIN 41 |
| Regular Season: Week 13 |
 Chargers |
at |
Bengals |
Sunday, December 5, 2021 |
1:00PM |
LAC 41, CIN 22 |
| Regular Season: Week 14 |
 49ers |
at |
Bengals |
Sunday, December 12, 2021 |
1:00PM |
SF 26, CIN 23 |
| Regular Season: Week 15 |
Bengals |
at |
 Broncos |
Sunday, December 19, 2021 |
4:05PM |
CIN 15, DEN 10 |
| Regular Season: Week 16 |
Ravens |
at |
Bengals |
Sunday, December 26, 2021 |
1:00PM |
BAL 21, CIN 41 |
| Regular Season: Week 17 |
 Chiefs |
at |
Bengals |
Sunday, January 2, 2022 |
1:00PM |
KC 31, CIN 34 |
| Regular Season: Week 18 |
Bengals |
at |
Browns |
Sunday, January 9, 2022 |
1:00PM |
CIN 16, CLE 21 |