| Regular Season: Week 1 |
 Bills |
at |
 Chargers |
Sunday, September 4, 1966 |
3:00PM |
BUF 7, SD 27 |
| Regular Season: Week 2 |
 Chiefs |
at |
Bills |
Sunday, September 11, 1966 |
3:00PM |
KC 42, BUF 20 |
| Regular Season: Week 3 |
 Dolphins |
at |
Bills |
Sunday, September 18, 1966 |
3:00PM |
MIA 24, BUF 58 |
| Regular Season: Week 4 |
 Oilers |
at |
Bills |
Sunday, September 25, 1966 |
3:00PM |
HOU 20, BUF 27 |
| Regular Season: Week 5 |
Bills |
at |
Chiefs |
Sunday, October 2, 1966 |
3:00PM |
BUF 29, KC 14 |
| Regular Season: Week 6 |
 Patriots |
at |
Bills |
Saturday, October 8, 1966 |
3:00PM |
BOS 20, BUF 10 |
| Regular Season: Week 7 |
Chargers |
at |
Bills |
Sunday, October 16, 1966 |
3:00PM |
SD 17, BUF 17 |
| Regular Season: Week 9 |
Bills |
at |
 Jets |
Sunday, October 30, 1966 |
2:00PM |
BUF 33, NYJ 23 |
| Regular Season: Week 10 |
Bills |
at |
Dolphins |
Sunday, November 6, 1966 |
3:00PM |
BUF 29, MIA 0 |
| Regular Season: Week 11 |
Jets |
at |
Bills |
Sunday, November 13, 1966 |
3:00PM |
NYJ 3, BUF 14 |
| Regular Season: Week 12 |
Bills |
at |
Oilers |
Sunday, November 20, 1966 |
3:00PM |
BUF 42, HOU 20 |
| Regular Season: Week 13 |
Bills |
at |
 Raiders |
Thursday, November 24, 1966 |
3:00PM |
BUF 31, OAK 10 |
| Regular Season: Week 14 |
Bills |
at |
Patriots |
Sunday, December 4, 1966 |
3:00PM |
BUF 3, BOS 14 |
| Regular Season: Week 16 |
 Broncos |
at |
Bills |
Sunday, December 18, 1966 |
3:00PM |
DEN 21, BUF 38 |
| Conference Championship: Week 17 |
Chiefs |
at |
Bills |
Sunday, January 1, 1967 |
3:00PM |
KC 31, BUF 7 |