| Regular Season: Week 1 |
 Patriots |
at |
 Bills |
Sunday, September 8, 1968 |
3:00PM |
BOS 16, BUF 7 |
| Regular Season: Week 1 |
 Raiders |
at |
Bills |
Sunday, September 15, 1968 |
3:00PM |
OAK 48, BUF 6 |
| Regular Season: Week 2 |
Bills |
at |
 Bengals |
Sunday, September 22, 1968 |
3:00PM |
BUF 23, CIN 34 |
| Regular Season: Week 3 |
 Jets |
at |
Bills |
Sunday, September 29, 1968 |
3:00PM |
NYJ 35, BUF 37 |
| Regular Season: Week 4 |
 Chiefs |
at |
Bills |
Saturday, October 5, 1968 |
3:00PM |
KC 18, BUF 7 |
| Regular Season: Week 5 |
Bills |
at |
 Dolphins |
Saturday, October 12, 1968 |
3:00PM |
BUF 14, MIA 14 |
| Regular Season: Week 6 |
Bills |
at |
Patriots |
Sunday, October 20, 1968 |
3:00PM |
BUF 6, BOS 23 |
| Regular Season: Week 7 |
 Oilers |
at |
Bills |
Sunday, October 27, 1968 |
2:00PM |
HOU 30, BUF 7 |
| Regular Season: Week 8 |
Bills |
at |
Jets |
Sunday, November 3, 1968 |
3:00PM |
BUF 21, NYJ 25 |
| Regular Season: Week 9 |
Dolphins |
at |
Bills |
Sunday, November 10, 1968 |
3:00PM |
MIA 21, BUF 17 |
| Regular Season: Week 10 |
 Chargers |
at |
Bills |
Sunday, November 17, 1968 |
3:00PM |
SD 21, BUF 6 |
| Regular Season: Week 11 |
Bills |
at |
 Broncos |
Sunday, November 24, 1968 |
3:00PM |
BUF 32, DEN 34 |
| Regular Season: Week 12 |
Bills |
at |
Raiders |
Thursday, November 28, 1968 |
3:00PM |
BUF 10, OAK 13 |
| Regular Season: Week 13 |
Bills |
at |
Oilers |
Saturday, December 7, 1968 |
3:00PM |
BUF 6, HOU 35 |