| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 14, 1969 |
3:00PM |
NYJ 33, BUF 19 |
| Regular Season: Week 2 |
 Oilers |
at |
Bills |
Sunday, September 21, 1969 |
3:00PM |
HOU 17, BUF 3 |
| Regular Season: Week 3 |
 Broncos |
at |
Bills |
Sunday, September 28, 1969 |
3:00PM |
DEN 28, BUF 41 |
| Regular Season: Week 4 |
Bills |
at |
Oilers |
Sunday, October 5, 1969 |
3:00PM |
BUF 14, HOU 28 |
| Regular Season: Week 5 |
 Patriots |
at |
Bills |
Saturday, October 11, 1969 |
3:00PM |
BOS 16, BUF 23 |
| Regular Season: Week 6 |
Bills |
at |
 Raiders |
Sunday, October 19, 1969 |
3:00PM |
BUF 21, OAK 50 |
| Regular Season: Week 7 |
Bills |
at |
 Dolphins |
Sunday, October 26, 1969 |
2:00PM |
BUF 6, MIA 24 |
| Regular Season: Week 8 |
 Chiefs |
at |
Bills |
Sunday, November 2, 1969 |
3:00PM |
KC 29, BUF 7 |
| Regular Season: Week 8 |
Bills |
at |
Jets |
Sunday, November 9, 1969 |
3:00PM |
BUF 6, NYJ 16 |
| Regular Season: Week 9 |
Dolphins |
at |
Bills |
Sunday, November 16, 1969 |
3:00PM |
MIA 3, BUF 28 |
| Regular Season: Week 10 |
Bills |
at |
Patriots |
Sunday, November 23, 1969 |
3:00PM |
BUF 21, BOS 35 |
| Regular Season: Week 11 |
 Bengals |
at |
Bills |
Sunday, November 30, 1969 |
3:00PM |
CIN 13, BUF 16 |
| Regular Season: Week 12 |
Bills |
at |
Chiefs |
Sunday, December 7, 1969 |
3:00PM |
BUF 19, KC 22 |
| Regular Season: Week 13 |
Bills |
at |
 Chargers |
Sunday, December 14, 1969 |
3:00PM |
BUF 6, SD 45 |