| Regular Season: Week 1 |
 Cowboys |
at |
 Bills |
Sunday, September 19, 1971 |
3:00PM |
DAL 49, BUF 37 |
| Regular Season: Week 2 |
 Dolphins |
at |
Bills |
Sunday, September 26, 1971 |
3:00PM |
MIA 29, BUF 14 |
| Regular Season: Week 3 |
Bills |
at |
 Vikings |
Sunday, October 3, 1971 |
3:00PM |
BUF 0, MIN 19 |
| Regular Season: Week 4 |
 Colts |
at |
Bills |
Sunday, October 10, 1971 |
3:00PM |
BAL 43, BUF 0 |
| Regular Season: Week 5 |
Bills |
at |
 Jets |
Sunday, October 17, 1971 |
3:00PM |
BUF 17, NYJ 28 |
| Regular Season: Week 6 |
Bills |
at |
 Chargers |
Saturday, October 23, 1971 |
3:00PM |
BUF 3, SD 20 |
| Regular Season: Week 7 |
 Cardinals |
at |
Bills |
Sunday, October 31, 1971 |
2:00PM |
STL 28, BUF 23 |
| Regular Season: Week 8 |
Bills |
at |
Dolphins |
Sunday, November 7, 1971 |
3:00PM |
BUF 0, MIA 34 |
| Regular Season: Week 9 |
Bills |
at |
 Patriots |
Sunday, November 14, 1971 |
3:00PM |
BUF 33, NE 38 |
| Regular Season: Week 10 |
Jets |
at |
Bills |
Sunday, November 21, 1971 |
3:00PM |
NYJ 20, BUF 7 |
| Regular Season: Week 11 |
Patriots |
at |
Bills |
Sunday, November 28, 1971 |
3:00PM |
NE 20, BUF 27 |
| Regular Season: Week 12 |
Bills |
at |
Colts |
Sunday, December 5, 1971 |
3:00PM |
BUF 0, BAL 24 |
| Regular Season: Week 13 |
 Oilers |
at |
Bills |
Sunday, December 12, 1971 |
3:00PM |
HOU 20, BUF 14 |
| Regular Season: Week 14 |
Bills |
at |
 Chiefs |
Sunday, December 19, 1971 |
3:00PM |
BUF 9, KC 22 |