| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 17, 1972 |
3:00PM |
NYJ 41, BUF 24 |
| Regular Season: Week 2 |
 49ers |
at |
Bills |
Sunday, September 24, 1972 |
3:00PM |
SF 20, BUF 27 |
| Regular Season: Week 3 |
 Colts |
at |
Bills |
Sunday, October 1, 1972 |
3:00PM |
BAL 17, BUF 0 |
| Regular Season: Week 4 |
 Patriots |
at |
Bills |
Sunday, October 8, 1972 |
3:00PM |
NE 14, BUF 38 |
| Regular Season: Week 5 |
Bills |
at |
 Raiders |
Sunday, October 15, 1972 |
3:00PM |
BUF 16, OAK 28 |
| Regular Season: Week 6 |
Bills |
at |
 Dolphins |
Sunday, October 22, 1972 |
3:00PM |
BUF 23, MIA 24 |
| Regular Season: Week 7 |
 Steelers |
at |
Bills |
Sunday, October 29, 1972 |
2:00PM |
PIT 38, BUF 21 |
| Regular Season: Week 8 |
Dolphins |
at |
Bills |
Sunday, November 5, 1972 |
3:00PM |
MIA 30, BUF 16 |
| Regular Season: Week 9 |
Bills |
at |
Jets |
Sunday, November 12, 1972 |
3:00PM |
BUF 3, NYJ 41 |
| Regular Season: Week 10 |
Bills |
at |
Patriots |
Sunday, November 19, 1972 |
3:00PM |
BUF 27, NE 24 |
| Regular Season: Week 11 |
Bills |
at |
 Browns |
Sunday, November 26, 1972 |
3:00PM |
BUF 10, CLE 27 |
| Regular Season: Week 12 |
Bills |
at |
Colts |
Sunday, December 3, 1972 |
3:00PM |
BUF 7, BAL 35 |
| Regular Season: Week 13 |
 Lions |
at |
Bills |
Sunday, December 10, 1972 |
3:00PM |
DET 21, BUF 21 |
| Regular Season: Week 14 |
Bills |
at |
 Redskins |
Sunday, December 17, 1972 |
3:00PM |
BUF 24, WAS 17 |