| Regular Season: Week 1 |
 Bills |
at |
 Patriots |
Sunday, September 16, 1973 |
3:00PM |
BUF 31, NE 13 |
| Regular Season: Week 2 |
Bills |
at |
 Chargers |
Sunday, September 23, 1973 |
3:00PM |
BUF 7, SD 34 |
| Regular Season: Week 3 |
 Jets |
at |
Bills |
Sunday, September 30, 1973 |
3:00PM |
NYJ 7, BUF 9 |
| Regular Season: Week 4 |
 Eagles |
at |
Bills |
Sunday, October 7, 1973 |
3:00PM |
PHI 26, BUF 27 |
| Regular Season: Week 5 |
 Colts |
at |
Bills |
Sunday, October 14, 1973 |
3:00PM |
BAL 13, BUF 31 |
| Regular Season: Week 6 |
Bills |
at |
 Dolphins |
Sunday, October 21, 1973 |
3:00PM |
BUF 6, MIA 27 |
| Regular Season: Week 7 |
 Chiefs |
at |
Bills |
Monday, October 29, 1973 |
3:00PM |
KC 14, BUF 23 |
| Regular Season: Week 8 |
Bills |
at |
 Saints |
Sunday, November 4, 1973 |
3:00PM |
BUF 0, NO 13 |
| Regular Season: Week 9 |
 Bengals |
at |
Bills |
Sunday, November 11, 1973 |
3:00PM |
CIN 16, BUF 13 |
| Regular Season: Week 10 |
Dolphins |
at |
Bills |
Sunday, November 18, 1973 |
3:00PM |
MIA 17, BUF 0 |
| Regular Season: Week 11 |
Bills |
at |
Colts |
Sunday, November 25, 1973 |
3:00PM |
BUF 24, BAL 17 |
| Regular Season: Week 12 |
Bills |
at |
 Falcons |
Sunday, December 2, 1973 |
3:00PM |
BUF 17, ATL 6 |
| Regular Season: Week 13 |
Patriots |
at |
Bills |
Sunday, December 9, 1973 |
3:00PM |
NE 13, BUF 37 |
| Regular Season: Week 14 |
Bills |
at |
Jets |
Sunday, December 16, 1973 |
3:00PM |
BUF 34, NYJ 14 |