| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 21, 1975 |
3:00PM |
NYJ 14, BUF 42 |
| Regular Season: Week 2 |
Bills |
at |
 Steelers |
Sunday, September 28, 1975 |
3:00PM |
BUF 30, PIT 21 |
| Regular Season: Week 3 |
 Broncos |
at |
Bills |
Sunday, October 5, 1975 |
3:00PM |
DEN 14, BUF 38 |
| Regular Season: Week 4 |
Bills |
at |
 Colts |
Sunday, October 12, 1975 |
3:00PM |
BUF 38, BAL 31 |
| Regular Season: Week 5 |
 Giants |
at |
Bills |
Monday, October 20, 1975 |
3:00PM |
NYG 17, BUF 14 |
| Regular Season: Week 6 |
 Dolphins |
at |
Bills |
Sunday, October 26, 1975 |
2:00PM |
MIA 35, BUF 30 |
| Regular Season: Week 7 |
Bills |
at |
Jets |
Sunday, November 2, 1975 |
3:00PM |
BUF 24, NYJ 23 |
| Regular Season: Week 8 |
Colts |
at |
Bills |
Sunday, November 9, 1975 |
3:00PM |
BAL 42, BUF 35 |
| Regular Season: Week 9 |
Bills |
at |
 Bengals |
Monday, November 17, 1975 |
3:00PM |
BUF 24, CIN 33 |
| Regular Season: Week 10 |
 Patriots |
at |
Bills |
Sunday, November 23, 1975 |
3:00PM |
NE 31, BUF 45 |
| Regular Season: Week 11 |
Bills |
at |
 Cardinals |
Thursday, November 27, 1975 |
3:00PM |
BUF 32, STL 14 |
| Regular Season: Week 12 |
Bills |
at |
Dolphins |
Sunday, December 7, 1975 |
3:00PM |
BUF 21, MIA 31 |
| Regular Season: Week 13 |
Bills |
at |
Patriots |
Sunday, December 14, 1975 |
3:00PM |
BUF 34, NE 14 |
| Regular Season: Week 14 |
 Vikings |
at |
Bills |
Saturday, December 20, 1975 |
3:00PM |
MIN 35, BUF 13 |