| Regular Season: Week 1 |
 Dolphins |
at |
 Bills |
Sunday, September 18, 1977 |
3:00PM |
MIA 13, BUF 0 |
| Regular Season: Week 2 |
Bills |
at |
 Broncos |
Sunday, September 25, 1977 |
3:00PM |
BUF 6, DEN 26 |
| Regular Season: Week 3 |
Bills |
at |
 Colts |
Sunday, October 2, 1977 |
3:00PM |
BUF 14, BAL 17 |
| Regular Season: Week 4 |
 Jets |
at |
Bills |
Sunday, October 9, 1977 |
3:00PM |
NYJ 24, BUF 19 |
| Regular Season: Week 5 |
 Falcons |
at |
Bills |
Sunday, October 16, 1977 |
3:00PM |
ATL 0, BUF 3 |
| Regular Season: Week 6 |
 Browns |
at |
Bills |
Sunday, October 23, 1977 |
3:00PM |
CLE 27, BUF 16 |
| Regular Season: Week 7 |
Bills |
at |
 Seahawks |
Sunday, October 30, 1977 |
2:00PM |
BUF 17, SEA 56 |
| Regular Season: Week 8 |
Bills |
at |
 Patriots |
Sunday, November 6, 1977 |
3:00PM |
BUF 24, NE 14 |
| Regular Season: Week 9 |
Colts |
at |
Bills |
Sunday, November 13, 1977 |
3:00PM |
BAL 31, BUF 13 |
| Regular Season: Week 10 |
Patriots |
at |
Bills |
Sunday, November 20, 1977 |
3:00PM |
NE 20, BUF 7 |
| Regular Season: Week 11 |
Bills |
at |
 Raiders |
Monday, November 28, 1977 |
3:00PM |
BUF 13, OAK 34 |
| Regular Season: Week 12 |
 Redskins |
at |
Bills |
Sunday, December 4, 1977 |
3:00PM |
WAS 10, BUF 0 |
| Regular Season: Week 13 |
Bills |
at |
Jets |
Sunday, December 11, 1977 |
3:00PM |
BUF 14, NYJ 10 |
| Regular Season: Week 14 |
Bills |
at |
Dolphins |
Saturday, December 17, 1977 |
3:00PM |
BUF 14, MIA 31 |