| Regular Season: Week 1 |
 Dolphins |
at |
 Bills |
Sunday, September 2, 1979 |
3:00PM |
MIA 9, BUF 7 |
| Regular Season: Week 2 |
 Bengals |
at |
Bills |
Sunday, September 9, 1979 |
3:00PM |
CIN 24, BUF 51 |
| Regular Season: Week 3 |
Bills |
at |
 Chargers |
Sunday, September 16, 1979 |
3:00PM |
BUF 19, SD 27 |
| Regular Season: Week 4 |
 Jets |
at |
Bills |
Sunday, September 23, 1979 |
3:00PM |
NYJ 31, BUF 46 |
| Regular Season: Week 5 |
Bills |
at |
 Colts |
Sunday, September 30, 1979 |
3:00PM |
BUF 31, BAL 13 |
| Regular Season: Week 6 |
 Bears |
at |
Bills |
Sunday, October 7, 1979 |
3:00PM |
CHI 7, BUF 0 |
| Regular Season: Week 7 |
Bills |
at |
Dolphins |
Sunday, October 14, 1979 |
3:00PM |
BUF 7, MIA 17 |
| Regular Season: Week 8 |
Colts |
at |
Bills |
Sunday, October 21, 1979 |
3:00PM |
BAL 14, BUF 13 |
| Regular Season: Week 9 |
Bills |
at |
 Lions |
Sunday, October 28, 1979 |
2:00PM |
BUF 20, DET 17 |
| Regular Season: Week 10 |
 Patriots |
at |
Bills |
Sunday, November 4, 1979 |
3:00PM |
NE 26, BUF 6 |
| Regular Season: Week 11 |
Bills |
at |
Jets |
Sunday, November 11, 1979 |
3:00PM |
BUF 14, NYJ 12 |
| Regular Season: Week 12 |
 Packers |
at |
Bills |
Sunday, November 18, 1979 |
3:00PM |
GB 12, BUF 19 |
| Regular Season: Week 13 |
Bills |
at |
Patriots |
Sunday, November 25, 1979 |
3:00PM |
BUF 16, NE 13 |
| Regular Season: Week 14 |
 Broncos |
at |
Bills |
Sunday, December 2, 1979 |
3:00PM |
DEN 19, BUF 16 |
| Regular Season: Week 15 |
Bills |
at |
 Vikings |
Sunday, December 9, 1979 |
3:00PM |
BUF 3, MIN 10 |
| Regular Season: Week 16 |
Bills |
at |
 Steelers |
Sunday, December 16, 1979 |
3:00PM |
BUF 0, PIT 28 |