| Regular Season: Week 1 |
 Dolphins |
at |
 Bills |
Sunday, September 7, 1980 |
3:00PM |
MIA 7, BUF 17 |
| Regular Season: Week 2 |
 Jets |
at |
Bills |
Sunday, September 14, 1980 |
3:00PM |
NYJ 10, BUF 20 |
| Regular Season: Week 3 |
Bills |
at |
 Saints |
Sunday, September 21, 1980 |
3:00PM |
BUF 35, NO 26 |
| Regular Season: Week 4 |
 Raiders |
at |
Bills |
Sunday, September 28, 1980 |
3:00PM |
OAK 7, BUF 24 |
| Regular Season: Week 5 |
Bills |
at |
 Chargers |
Sunday, October 5, 1980 |
3:00PM |
BUF 26, SD 24 |
| Regular Season: Week 6 |
 Colts |
at |
Bills |
Sunday, October 12, 1980 |
3:00PM |
BAL 17, BUF 12 |
| Regular Season: Week 7 |
Bills |
at |
Dolphins |
Sunday, October 19, 1980 |
3:00PM |
BUF 14, MIA 17 |
| Regular Season: Week 8 |
 Patriots |
at |
Bills |
Sunday, October 26, 1980 |
2:00PM |
NE 13, BUF 31 |
| Regular Season: Week 9 |
 Falcons |
at |
Bills |
Sunday, November 2, 1980 |
3:00PM |
ATL 30, BUF 14 |
| Regular Season: Week 10 |
Bills |
at |
Jets |
Sunday, November 9, 1980 |
3:00PM |
BUF 31, NYJ 24 |
| Regular Season: Week 11 |
Bills |
at |
 Bengals |
Sunday, November 16, 1980 |
3:00PM |
BUF 14, CIN 0 |
| Regular Season: Week 12 |
 Steelers |
at |
Bills |
Sunday, November 23, 1980 |
3:00PM |
PIT 13, BUF 28 |
| Regular Season: Week 13 |
Bills |
at |
Colts |
Sunday, November 30, 1980 |
3:00PM |
BUF 24, BAL 28 |
| Regular Season: Week 14 |
 Rams |
at |
Bills |
Sunday, December 7, 1980 |
3:00PM |
LA 7, BUF 10 |
| Regular Season: Week 15 |
Bills |
at |
Patriots |
Sunday, December 14, 1980 |
3:00PM |
BUF 2, NE 24 |
| Regular Season: Week 16 |
Bills |
at |
 49ers |
Sunday, December 21, 1980 |
3:00PM |
BUF 18, SF 13 |
| Divisional Playoffs: Week 18 |
Bills |
at |
Chargers |
Saturday, January 3, 1981 |
3:00PM |
BUF 14, SD 20 |