| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 6, 1981 |
3:00PM |
NYJ 0, BUF 31 |
| Regular Season: Week 2 |
Bills |
at |
 Colts |
Sunday, September 13, 1981 |
3:00PM |
BUF 35, BAL 3 |
| Regular Season: Week 3 |
 Eagles |
at |
Bills |
Thursday, September 17, 1981 |
3:00PM |
PHI 20, BUF 14 |
| Regular Season: Week 4 |
Bills |
at |
 Bengals |
Sunday, September 27, 1981 |
3:00PM |
BUF 24, CIN 27 |
| Regular Season: Week 5 |
Colts |
at |
Bills |
Sunday, October 4, 1981 |
3:00PM |
BAL 17, BUF 23 |
| Regular Season: Week 6 |
 Dolphins |
at |
Bills |
Monday, October 12, 1981 |
3:00PM |
MIA 21, BUF 31 |
| Regular Season: Week 7 |
Bills |
at |
Jets |
Sunday, October 18, 1981 |
3:00PM |
BUF 14, NYJ 33 |
| Regular Season: Week 8 |
 Broncos |
at |
Bills |
Sunday, October 25, 1981 |
2:00PM |
DEN 7, BUF 9 |
| Regular Season: Week 9 |
 Browns |
at |
Bills |
Sunday, November 1, 1981 |
3:00PM |
CLE 13, BUF 22 |
| Regular Season: Week 10 |
Bills |
at |
 Cowboys |
Monday, November 9, 1981 |
3:00PM |
BUF 14, DAL 27 |
| Regular Season: Week 11 |
Bills |
at |
 Cardinals |
Sunday, November 15, 1981 |
3:00PM |
BUF 0, STL 24 |
| Regular Season: Week 12 |
 Patriots |
at |
Bills |
Sunday, November 22, 1981 |
3:00PM |
NE 17, BUF 20 |
| Regular Season: Week 13 |
 Redskins |
at |
Bills |
Sunday, November 29, 1981 |
3:00PM |
WAS 14, BUF 21 |
| Regular Season: Week 14 |
Bills |
at |
 Chargers |
Sunday, December 6, 1981 |
3:00PM |
BUF 28, SD 27 |
| Regular Season: Week 15 |
Bills |
at |
Patriots |
Sunday, December 13, 1981 |
3:00PM |
BUF 19, NE 10 |
| Regular Season: Week 16 |
Bills |
at |
Dolphins |
Saturday, December 19, 1981 |
3:00PM |
BUF 6, MIA 16 |
| Wild Card: Week 17 |
Bills |
at |
Jets |
Sunday, December 27, 1981 |
3:00PM |
BUF 31, NYJ 27 |
| Divisional Playoffs: Week 18 |
Bills |
at |
Bengals |
Sunday, January 3, 1982 |
3:00PM |
BUF 21, CIN 28 |