| Regular Season: Week 1 |
 Chargers |
at |
 Bills |
Sunday, September 8, 1985 |
3:00PM |
SD 14, BUF 9 |
| Regular Season: Week 2 |
Bills |
at |
 Jets |
Sunday, September 15, 1985 |
3:00PM |
BUF 3, NYJ 42 |
| Regular Season: Week 3 |
 Patriots |
at |
Bills |
Sunday, September 22, 1985 |
3:00PM |
NE 17, BUF 14 |
| Regular Season: Week 4 |
 Vikings |
at |
Bills |
Sunday, September 29, 1985 |
3:00PM |
MIN 27, BUF 20 |
| Regular Season: Week 5 |
Bills |
at |
 Colts |
Sunday, October 6, 1985 |
3:00PM |
BUF 17, IND 49 |
| Regular Season: Week 6 |
Bills |
at |
Patriots |
Sunday, October 13, 1985 |
3:00PM |
BUF 3, NE 14 |
| Regular Season: Week 7 |
Colts |
at |
Bills |
Sunday, October 20, 1985 |
3:00PM |
IND 9, BUF 21 |
| Regular Season: Week 8 |
Bills |
at |
 Eagles |
Sunday, October 27, 1985 |
2:00PM |
BUF 17, PHI 21 |
| Regular Season: Week 9 |
 Bengals |
at |
Bills |
Sunday, November 3, 1985 |
3:00PM |
CIN 23, BUF 17 |
| Regular Season: Week 10 |
 Oilers |
at |
Bills |
Sunday, November 10, 1985 |
3:00PM |
HOU 0, BUF 20 |
| Regular Season: Week 11 |
Bills |
at |
 Browns |
Sunday, November 17, 1985 |
3:00PM |
BUF 7, CLE 17 |
| Regular Season: Week 12 |
 Dolphins |
at |
Bills |
Sunday, November 24, 1985 |
3:00PM |
MIA 23, BUF 14 |
| Regular Season: Week 13 |
Bills |
at |
Chargers |
Sunday, December 1, 1985 |
3:00PM |
BUF 7, SD 40 |
| Regular Season: Week 14 |
Jets |
at |
Bills |
Sunday, December 8, 1985 |
3:00PM |
NYJ 27, BUF 7 |
| Regular Season: Week 15 |
Bills |
at |
 Steelers |
Sunday, December 15, 1985 |
3:00PM |
BUF 24, PIT 30 |
| Regular Season: Week 16 |
Bills |
at |
Dolphins |
Sunday, December 22, 1985 |
3:00PM |
BUF 0, MIA 28 |