| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 7, 1986 |
3:00PM |
NYJ 28, BUF 24 |
| Regular Season: Week 2 |
Bills |
at |
 Bengals |
Sunday, September 14, 1986 |
3:00PM |
BUF 33, CIN 36 |
| Regular Season: Week 3 |
 Cardinals |
at |
Bills |
Sunday, September 21, 1986 |
3:00PM |
STL 10, BUF 17 |
| Regular Season: Week 4 |
 Chiefs |
at |
Bills |
Sunday, September 28, 1986 |
3:00PM |
KC 20, BUF 17 |
| Regular Season: Week 5 |
Bills |
at |
Jets |
Sunday, October 5, 1986 |
3:00PM |
BUF 13, NYJ 14 |
| Regular Season: Week 6 |
Bills |
at |
 Dolphins |
Sunday, October 12, 1986 |
3:00PM |
BUF 14, MIA 27 |
| Regular Season: Week 7 |
 Colts |
at |
Bills |
Sunday, October 19, 1986 |
3:00PM |
IND 13, BUF 24 |
| Regular Season: Week 8 |
 Patriots |
at |
Bills |
Sunday, October 26, 1986 |
2:00PM |
NE 23, BUF 3 |
| Regular Season: Week 9 |
Bills |
at |
 Buccaneers |
Sunday, November 2, 1986 |
3:00PM |
BUF 28, TB 34 |
| Regular Season: Week 10 |
 Steelers |
at |
Bills |
Sunday, November 9, 1986 |
3:00PM |
PIT 12, BUF 16 |
| Regular Season: Week 11 |
Dolphins |
at |
Bills |
Sunday, November 16, 1986 |
3:00PM |
MIA 34, BUF 24 |
| Regular Season: Week 12 |
Bills |
at |
Patriots |
Sunday, November 23, 1986 |
3:00PM |
BUF 19, NE 22 |
| Regular Season: Week 13 |
Bills |
at |
Chiefs |
Sunday, November 30, 1986 |
3:00PM |
BUF 17, KC 14 |
| Regular Season: Week 14 |
 Browns |
at |
Bills |
Sunday, December 7, 1986 |
3:00PM |
CLE 21, BUF 17 |
| Regular Season: Week 15 |
Bills |
at |
Colts |
Sunday, December 14, 1986 |
3:00PM |
BUF 14, IND 24 |
| Regular Season: Week 16 |
Bills |
at |
 Oilers |
Sunday, December 21, 1986 |
3:00PM |
BUF 7, HOU 16 |