| Regular Season: Week 1 |
 Vikings |
at |
 Bills |
Sunday, September 4, 1988 |
3:00PM |
MIN 10, BUF 13 |
| Regular Season: Week 2 |
 Dolphins |
at |
Bills |
Sunday, September 11, 1988 |
3:00PM |
MIA 6, BUF 9 |
| Regular Season: Week 3 |
Bills |
at |
 Patriots |
Sunday, September 18, 1988 |
3:00PM |
BUF 16, NE 14 |
| Regular Season: Week 4 |
 Steelers |
at |
Bills |
Sunday, September 25, 1988 |
3:00PM |
PIT 28, BUF 36 |
| Regular Season: Week 5 |
Bills |
at |
 Bears |
Sunday, October 2, 1988 |
3:00PM |
BUF 3, CHI 24 |
| Regular Season: Week 6 |
 Colts |
at |
Bills |
Sunday, October 9, 1988 |
3:00PM |
IND 23, BUF 34 |
| Regular Season: Week 7 |
Bills |
at |
 Jets |
Monday, October 17, 1988 |
3:00PM |
BUF 37, NYJ 14 |
| Regular Season: Week 8 |
Patriots |
at |
Bills |
Sunday, October 23, 1988 |
3:00PM |
NE 20, BUF 23 |
| Regular Season: Week 9 |
 Packers |
at |
Bills |
Sunday, October 30, 1988 |
2:00PM |
GB 0, BUF 28 |
| Regular Season: Week 10 |
Bills |
at |
 Seahawks |
Sunday, November 6, 1988 |
3:00PM |
BUF 13, SEA 3 |
| Regular Season: Week 11 |
Bills |
at |
Dolphins |
Monday, November 14, 1988 |
3:00PM |
BUF 31, MIA 6 |
| Regular Season: Week 12 |
Jets |
at |
Bills |
Sunday, November 20, 1988 |
3:00PM |
NYJ 6, BUF 9 |
| Regular Season: Week 13 |
Bills |
at |
 Bengals |
Sunday, November 27, 1988 |
3:00PM |
BUF 21, CIN 35 |
| Regular Season: Week 14 |
Bills |
at |
 Buccaneers |
Sunday, December 4, 1988 |
3:00PM |
BUF 5, TB 10 |
| Regular Season: Week 15 |
 Raiders |
at |
Bills |
Sunday, December 11, 1988 |
3:00PM |
RAI 21, BUF 37 |
| Regular Season: Week 16 |
Bills |
at |
Colts |
Sunday, December 18, 1988 |
3:00PM |
BUF 14, IND 17 |
| Divisional Playoffs: Week 18 |
 Oilers |
at |
Bills |
Sunday, January 1, 1989 |
3:00PM |
HOU 10, BUF 17 |
| Conference Championship: Week 19 |
Bills |
at |
Bengals |
Sunday, January 8, 1989 |
3:00PM |
BUF 10, CIN 21 |