| Regular Season: Week 1 |
 Bills |
at |
 Dolphins |
Sunday, September 10, 1989 |
3:00PM |
BUF 27, MIA 24 |
| Regular Season: Week 2 |
 Broncos |
at |
Bills |
Monday, September 18, 1989 |
3:00PM |
DEN 28, BUF 14 |
| Regular Season: Week 3 |
Bills |
at |
 Oilers |
Sunday, September 24, 1989 |
3:00PM |
BUF 47, HOU 41 |
| Regular Season: Week 4 |
 Patriots |
at |
Bills |
Sunday, October 1, 1989 |
3:00PM |
NE 10, BUF 31 |
| Regular Season: Week 5 |
Bills |
at |
 Colts |
Sunday, October 8, 1989 |
3:00PM |
BUF 14, IND 37 |
| Regular Season: Week 6 |
 Rams |
at |
Bills |
Monday, October 16, 1989 |
3:00PM |
RAM 20, BUF 23 |
| Regular Season: Week 7 |
 Jets |
at |
Bills |
Sunday, October 22, 1989 |
3:00PM |
NYJ 3, BUF 34 |
| Regular Season: Week 8 |
Dolphins |
at |
Bills |
Sunday, October 29, 1989 |
2:00PM |
MIA 17, BUF 31 |
| Regular Season: Week 9 |
Bills |
at |
 Falcons |
Sunday, November 5, 1989 |
3:00PM |
BUF 28, ATL 30 |
| Regular Season: Week 10 |
Colts |
at |
Bills |
Sunday, November 12, 1989 |
3:00PM |
IND 7, BUF 30 |
| Regular Season: Week 11 |
Bills |
at |
Patriots |
Sunday, November 19, 1989 |
3:00PM |
BUF 24, NE 33 |
| Regular Season: Week 12 |
 Bengals |
at |
Bills |
Sunday, November 26, 1989 |
3:00PM |
CIN 7, BUF 24 |
| Regular Season: Week 13 |
Bills |
at |
 Seahawks |
Monday, December 4, 1989 |
3:00PM |
BUF 16, SEA 17 |
| Regular Season: Week 14 |
 Saints |
at |
Bills |
Sunday, December 10, 1989 |
3:00PM |
NO 22, BUF 19 |
| Regular Season: Week 15 |
Bills |
at |
 49ers |
Sunday, December 17, 1989 |
3:00PM |
BUF 10, SF 21 |
| Regular Season: Week 16 |
Bills |
at |
Jets |
Saturday, December 23, 1989 |
3:00PM |
BUF 37, NYJ 0 |
| Divisional Playoffs: Week 18 |
Bills |
at |
 Browns |
Saturday, January 6, 1990 |
3:00PM |
BUF 30, CLE 34 |